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深低温停循环对婴幼儿心脏手术围术期的影响 被引量:3

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摘要 目的探讨深低温停循环(DHCA)在婴幼儿复杂先天性心脏病矫治术中的脑保护效果及对围手术期肾功能、凝血系统的影响。方法回顾我院2006年1月~2008年12月74例术中应用DHCA的复杂先心患儿,并与同期应用常规体外循环患儿进行对照。所有病例均采用Stockert-Ⅲ型体外循环机转流,Dedico-901膜肺,红细胞及血浆预充,建立体外循环后肛温降到30℃时阻断升主动脉,灌注心肌停搏液。继续降温至鼻咽温18~20℃,肛温18~21℃,停循环时先停止动脉血泵的灌注,麻醉医生鼓肺、外科医生挤压肝区使体内血液回流入贮血室。钳夹动静脉输血管后氧合器自身循环。DHCA期间患儿头部冰敷。恢复体外循环后低温转流后再开始血流复温,并加入20%甘露醇、甲基强的松龙等。其中降温过程采用pH稳态,维持和复温过程采用α稳态分析,采用常规加改良超滤。结果除术后第3天肾功能、腹透例数、引流量外,其他神经系统、凝血系统两组间无统计学差异。结论在婴幼儿复杂心脏手术体外循环中,选择合适的血气管理模式,适当的控制降温和复温过程,维持较高的红细胞压积,改良超滤的应用等进一步改善DHCA脑保护效果,减少手术并发症,是成熟的脑保护措施。
作者 彭东
出处 《南方医科大学学报》 CAS CSCD 北大核心 2010年第2期409-410,412,共3页 Journal of Southern Medical University
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  • 1Muller D, Fieguth HG, Wimmer-Greinecker G, et al. Neurologic outcome atter surgery of the aortic arch: Comparison of deep hypothermic arrest, antegrade and retrograde cerebral perfusion [J ]. Indian J Thorac Cardiovasc Surg, 2004, 20: 72-6.
  • 2Yagdi T, Atay Y, Cikirikcioglu M, et al. Determinants of early mortality and neurological morbidity in aortic operations performed under circulatory arrest [ J ]. J Card Surg, 2000, 15:186-93.
  • 3Reich DL, Uysal S, Sliwinski M, et al. Neuropsychologic outcome after deep hypothermic circulatory arrest in adults [J]. J Thorac Cardiaovasc Surg, 1999, 117: 156-63.
  • 4Hagl C, Ergin MA, Galla JD, et al. Neurologic outcome after ascending aorta-aortic aerch operations: effect of brain protection technique in high-risk pations [ J ]. J Thorac Cardiovasc Surg, 2001, 121: 1107-21.
  • 5Fortescue EB, Bates DW, Chertow GM. Predicting acute renal failure after coronary bypass surgery: crossvalidation of two risk-stratification algorithms [ J ]. Kidney Int, 2000, 57: 594-602.
  • 6Winkler M, Akca O, Birkenberg B, et al. Aggressive warming reduces blood loss during hip arthroplasty [ J ]. Anesth Analg, 2000, 91: 978-84.
  • 7DiNardo J. Physiology and techniques of extracorporeal circulation in the pediatric patient [M ]//Lake CL, Booker PD. Pediatric cardiac anesthesia. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2005: 228-52.
  • 8Boldt J, Knothe C, Zickmann B, et al. Aprotinin in pediatric cardiac operations: platelet function, blood loss and use of homologous blood[J]. Ann Thorsc Surg, 1993, 55: 1460-6.
  • 9Kern FH, Morana N J, Sears J J, et al. Coagulation defects in neonates during cardiopulmonary bypass [J]. Ann Thorac Surg, 1992, 54: 541-6.
  • 10Horkay F, Martin P, Rajah M, et al. Response to heparinization in adults and children undergoing cardiac operations [J]. Ann Thorac Surg, 1992, 53: 822-6.

同被引文献28

  • 1吴维伟,李俊,徐建军,曹秀华,崔秀明.选择性脑灌注最适温度的实验研究[J].中国体外循环杂志,2004,2(3):159-162. 被引量:3
  • 2郦志军,尹小妹,叶箭.Effects of pH management during deep hypothermic bypass on cerebral oxygenation: alpha-stat versus pH-stat[J].Journal of Zhejiang University Science,2004,5(10):1290-1297. 被引量:9
  • 3蒋玲.低温体外循环心内直视术中a稳态和PH稳态的对比研究[J].实用预防医学,2006,13(5):1169-1171. 被引量:1
  • 4Shihata M,Mittal R,Senthilselvan A,et al.Selective antegrade cerebral perfusion during aortic arch surgery confers survival and neuropro- tective advantages[J].J Thorac Cardiovasc Surg, 2011,141 (4) :948-952.
  • 5Visconti K J,Rimmer D,Gauvreau K,et al.Regional low-flow perfusion versus circulatory arrest in neonates:one-year neurodevelopmental outcome[J].Ann Thorae Surg, 2006,82 ( 6 ) : 2207-2211.
  • 6Goldberg C S,Bove E L,Devaney E J,et al.A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest:outcomes for infants with functional single ventricle[J].J Thorac Cardiovasc Surg, 2007,133(4) : 880-887.
  • 7Morales D L,Scully P T,Braud B E,et al.Interrupted aortic arch repair:aortic arch advancement without a patch minimizes arch reinter- ventions[J].Ann Thorac Surg,2006,82(5) : 1577-1583.
  • 8Tlaskal T, Vojtovic P, Reich O, et al.Improved results after the primary repair of interrupted aortic arch :impact of a new management protocol with isolated cerebral perfusion[J].Eur J Cardiothorac Surg, 2010, 38( 1 ) : 52-58.
  • 9Algra S O,Kommann V N,van der Tweel I,et al.Increasing duration of circulatory arrest,but not antegrade cerebral perfusion, prolongs postoperative recovery after neonatal cardiac surgery[J].J Thorac Cardiovasc Surg,2012,143(2) :375-382.
  • 10Algra S O,Schouten A N,Oeveren W,et al.Low-flow antegrade cerebral perfusion attenuates early renal and intestinal injury during neonatal aortic arch reconstruction[J].J Thorac Cardiovasc Surg, 2012, 144(6) : 1323-1328.

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