原发性小肠恶性肿瘤120例临床研究

Clinical research of 120 cases of primary small intestine malignant tumor

目的研究原发性小肠恶性肿瘤的临床特点、病理类型、诊疗方法及预后。方法对120例经病理证实的原发性小肠恶性肿瘤临床病例进行回顾性分析。结果120例原发性小肠恶性肿瘤患者主要临床表现为腹痛、消化道出血、贫血、腹部肿块、黄疸。经腹部X线、消化道钡剂造影、CT、MRI等影像学手段以及纤维内镜取活组织检查或手术探查确诊。十二指肠为高发部位,占54.1%,病理类型以腺癌为主,占55.8%。中位生存期19.2个月,1年生存率55.4%,小肠腺癌接受化疗者的生存期和1年生存率与未化疗者相比无统计学意义(P=0.842)。结论原发性小肠恶性肿瘤缺乏典型的临床表现,应尽早诊断及手术治疗。

Objective To study the clinical and pathological features, diagnosis, therapy and prognosis of primary small intestine malignant tumor. Methods A retrospective analysis was performed on the clinical data from the 120 cases of primary small intestine malignant tumor. Results Abdominal pain, gastrointestinal bleeding, anemia, abdominal mass and jaundice were the main clinical features. The pathology was confirmed by abdominal X-ray, gastrointestinal barium, CT, MRI, endoscopy and surgical exploration. Most tumors originated in the duodenum （54.1%）, and adenocarcinoma （55.8%） was the main pathological type. The median survival time of the patients was 19.2 months and the 1-year survival rate was 55.4%. Chemotherapy did not seem to significantly improve the 1-year survival rate of the patients （P=0.842）. Conclusion Primary small intestine malignant tumors lack specific clinical manifestations and surgical resection should be performed as early as possible.