甲基转移酶与鼻咽癌放疗敏感性的相关性研究

Correlation of O6-methylguanine-DNA methyltransferase to radiation sensitivity of nasopharyngeal carcinoma

目的探讨O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)与鼻咽癌放疗敏感性的相关性。方法随机选择80例鼻咽癌患者,应用免疫组织化学技术测量MGMT含量后分为低MGMT组(18例)和高MGMT组(62例)作为对照,然后对放射敏感性进行统计学比较分析。结果低MGMT组放射高度敏感率15/18(83.3%),低度敏感率3/18(16.7%);高MGMT组放射高度敏感率28/62(45.2%),低度敏感率34/62(54.8%)。两组比较有显著统计学意义(χ2=4.393;P=0.036<0.05)。结论MGMT含量与鼻咽癌放疗敏感性明显相关,测定MGMT含量预测鼻咽癌放疗敏感性有一定的临床价值。

Objective To assess the correlation of O6-methylguanine-DNA methyltransferase （MGMT） to radiation sensitivity of nasopharyngeal carcinoma （NPC）. Methods Eighty randomly selected NPC patients were divided into high （＋/＋＋, n=62） and low （-/±, n=18）MGMT groups according to the results of MGMT detection using immunohistochemistry. All the patients received irradiation with external beam radiotherapy, and the radiation sensitivity of NPC was analyzed after the irradiation. Results The rates of high and low radiation sensitivity were 83.3% and 16.7% in low MGMT group, respectively, showing significant differences from those of the high MGMT group （45.2% and 54.8%, respectively, χ2=4.393, P=0.036）. Conclusion The content of MGMT correlates to the radiation sensitivity of NPC and may serve as valuable indicators for predicting the radiation sensitivity of NPC.