摘要
目的:对微孔载药支架与可降解聚合物药物涂层支架治疗急性冠脉综合征(ACS)6个月的临床疗效及安全性进行对比研究。方法:采用随机、对照的研究方法,入选120例ACS住院患者,根据所置入支架分为YINYI组(n=60)和EXCEL组(n=60)。平均随访6个月;以主要不良心脏事件(MACE)、支架内再狭窄(ISR)率、直径狭窄程度和晚期管腔丢失(LLL)为研究终点,评价YINYI和EXCEL支架治疗ACS的安全性和临床效果。结果:随访期内两组MACE发生率均为0,YINYI组13例和EXCEL组10例于术后接受了定量冠状动脉造影随访。ISR发生率分别为0,直径再狭窄率分别为(6.32±5.32)%和(6.85±5.53)%,LLL分别为(-0.03±0.05)mm和(-0.03±0.07)mm,上述各项指标差异均无统计学意义(P>0.05)。结论:微孔载药支架(YINYI)与可降解聚合物药物涂层支架(EXCEL)治疗ACS至少在6个月内安全有效,二者在临床疗效及安全性方面无显著性差异。
Objective:To evaluate the safety and efficacy of the drug-loaded microporous stent and the biodegradable polymer stent in patients with Acute coronary syndrome m six months.Methods:In this random and comparative study,120 in-hospital patients with ACS were divided into YINYI group and EXCEL group by corresponding standards. The average follow-up for 6 months;The safety and efficacy of YINYI and EXCEL stent was evaluated by major adverse cardiac events (MACE),in-stent restenosis (ISR) rate,percent diameter stenosis rate as well as late luminal loss LLL) at six months post stenting.Results: Quantitative coronary angiography (QCA) analysis were available in t3 patients in YINYI group and 10 patients in EXCEL group.In both groups.MACE was 0.ISR rates was 0.Percem diameter stenosis rate[(6.32± 5.32)% vs (6.85±5.53)%],LLL[(-0.03±0.05)mm vs (-0.03±0.07)mm],respectively. Conelusion:lt was safe and effective in the patients suffering from ACS treated with The drag-loaded microporous stent[YINYI)and the drug-eluting stent with biodegradable polymer (EXCEL) at least 6 months.The two sorts of stents can obtain satisfactory short-term clinical results in the aspects of lowering MACE,preventing ISR,reducing the LLL,and there were no significant differences between them in the aspects of safety and efficacy.
出处
《中国医药导刊》
2010年第3期357-359,共3页
Chinese Journal of Medicinal Guide
关键词
微孔载药
可降解聚合物
支架
急性瓶脉综合征
Drug-loaded microporous stent
Biodegradable polymer
Acute coronary syndrome