三种喹诺酮类药三联方对幽门螺杆菌体内外抗菌效果对比研究

In Vivo and Vitro Antibiatic Offects of 3 Quinalones Triple Therapy Against Hp:Controlle Study

目的:评价三种喹诺酮类药与阿莫西林对180株幽门螺杆菌(Hp)体外联合抗菌效应和临床根除率。方法:测定三种喹诺酮类药(环丙沙星、左氧氟沙星、莫西沙星)分别与阿莫西林单用及联用对180株Hp的最低抑菌浓度(MIC),计算其联合药敏指数(FIC值),并观察三种喹诺酮类药与奥美拉唑三联方根除Hp感染的疗效。结果:三种喹诺酮类药与阿莫西林联用对Hp致病菌的MIC值均显著降低。环丙沙星FIC值:0.75～1为相加作用;左氧氟沙星FIC值0.5～0.75为相加作用,莫西沙星FIC值;0.09375～0.1875为协同作用。三种喹诺酮类药与奥美拉唑的三联方对Hp临床根除率分别为93.33%、73.33%和61.67%,P<0.05。结论:三种喹诺酮类药与阿莫西林联用对180株Hp抗菌作用增强以协同作用和相加作用为主,无拮抗效应,其Hp根除率排序:莫西沙星>左氧氟沙星>环丙沙星。

Objective：To valuate the antibiotic effects in vitro of 3 quinolones combined with Amoxillin against 180 Helicobacter pylori（Hp） and Hp eradication rate in Our Hospital clinic.Methods：The MIC of ciprofloxacin and Amoxillin,Levofloxacin and Amorillin,Moxilloxacin and Amoxillin alone or in combination against 180 strains Hp were detected and FIC index was calculated according to MIC values.To obverse the curative effect of 3 quinolones and omeprazole tripl therapy on eradication of Hp infection.Results：The MIC of 3 quinolones combined with Amoxillin against Hp was reduced significantly.FIC index of ciprofloxacin 0.75--1.0 was additive action;FIC index of Levoftoxacin;0.5-0.75 was additive action.FIC index of Moxifloxacin：0.09375-0.1875 was synergism action,The Hp eradication rate in Our clinic of 3 quinalones and Omeprazole tripl therapy was 93.33%, 73.33% and 61.67%,respectively.P〈0.05.Conelusion：The antibiotic activity of 3 quinolones combined with Amoxillin against t 80 ttp strains was enhanced significantly.Their was characterized by synergism and additive action instead of antagonistic effect.The Hp eradication rate was Moxifloxacin〉lovefloxacin〉Ciprofloxacin.