胱抑素C与尿mAlb和尿β_2-MG检测在糖尿病肾病早期诊断中的应用

Serum Cystatin C,Urine mAlb and β_2-MG Detection in Early Diagnosis of Diabetic Nephropathy

目的:探讨应用血清胱抑素C、尿微量白蛋白和尿β_2-微球蛋白检测做糖尿病肾病早期诊断。方法:分别测定:DN组57例糖尿病肾病患者、NDN组42例无糖尿病肾病的糖尿病患者和对照组54例健康人血清胱抑素C、晨尿中的微量白蛋白(mAlb)和尿β_2-微球蛋白(β_2-MG)的水平。结果:DN组与NDN组及对照组比较,血清胱抑素C、尿mAlb和尿β_2-MG的含量均明显增高(P<0.05),差异有显著性统计学意义。而NDN组及对照组比较,血清胱抑素C、尿mAlb和尿β_2-MG的含量均无明显变化(P<0.05),差异无显著性统计学意义。结论:糖尿病肾病早期肾损害与血清胱抑素C、尿微量白蛋白和尿β_2-微球蛋白密切相关,血清胱抑素C、尿微量白蛋白和β_2-微球蛋白是反映早期糖尿病肾病的敏感指标,对于监测DN的发生和病情发展程度有重要意义。

Objective：To evaluate serum cystatin C,urinary albumin and urinary β2-microglobulin detection in early diagnosis of diabetic nephropathy.Methods：Were measured：DN group of 57 patients with diabetic nephropathy,NDN group of 42 patients with non-diabetic nephropathy in diabetes patients and healthy control group,54 cases of serum cystatin C,morning urine microalbumin（mAlb）and urinary β2- microglobulin（β2-MG）level.Resnlts：DN group and the NDN group and control group,serum eystatin C,urine mAlb and β2-MG levels were significantly higher（P〈0.05）,there are significant differences.The NDN group and control group,serum cystatin C,urine mAlb and urinary β2- MG levels were no significant changes（P〉0.05）,there was no significant difference.Conclusion：Early renal damage in diabetic nephropathy and serum cystatin C,urinary albumin and urinary β2-microglobulin is closely related to cystatin C,urinary albumin and urinary ,β2-microgtobulin reflects the early stage of diabetic nephropathy sensitive indicator for monitoring the occurrence and progression of the disease DN degree of significance.