原发性高脂血症中医证型与客观指标相关性研究

Research on associativity of TCM syndrome and objective indexes of primary hyperlipemia

目的:探讨高脂血症中医证型规律及与年龄、性别、体质量指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、载脂蛋白ApoAI、ApoB的相关性。方法:对120例原发性高脂血症患者进行中医辨证分型,运用Logistic回归分析对客观指标和中医证型的相关性进行对照分析,探讨其相关性。结果:回归分析显示原发性高脂血症的中医证型与血脂指标、年龄、性别、BMI之间有一定的相关性。结论:痰浊阻遏证与脾肾阳虚证为主要证型,原发性高脂血症的中医证型与年龄、性别、体质量指数、血脂指标之间有一定的相关性,可以考虑为中医辨证分型客观化提供理论基础。脾肾亏虚、痰瘀互结是原发性高脂血症的重要病机。辨治上以健脾益肾、益气养心、活血化痰为法,取得了很好的效果。

Objective： To probe into TCM pattern of primary hyperlipemia and its relationship with gender, age, BMI, laboratory indices such as TC,TG, LDL-C, HDL-C, ApoAI, ApoB of the 120 patients with primary hyperlipemia. Methods： Logistic regression analysis wan used to analyze the associativity of TCM syndrome and objective indexes of primary hyperlipemia. Results： Logistic regression analysis showed that TCM syndromes of primary hyperlipemia had some relation with laboratory indices. Conclusion： TCM syndromes of primary hyperlipemia had some relation with laboratory indices. The lipemia laboratory indices can be one of the objective basis of TCM diagnosis. The main syndromes were stagnation of phlegm-turbid and syndrome of yang deficiency of both of spleen and kidney, the main pathogenesis were deficiency of spleen and kidney, intermingled phlegm and blood stasis. The main treatment methods were invigorating spleen and tonifying kidney, supplementing qi and nourishing heart, promoting blood flow and dissipating phlegm.