紫杉醇脂质体加顺铂联合放疗治疗恶性肿瘤的疗效和安全性研究

Effectiveness and safety of paclitaxel liposomes plus cisplatin combined with radiotherapy for malignant tumors

目的观察放疗联合紫杉醇脂质体加顺铂同期治疗恶性肿瘤的近期疗效和毒副作用。方法26例恶性肿瘤患者采用紫杉醇脂质体联合顺铂化疗2～4个周期,同期给予放射治疗。结果26例患者中可评价近期疗效16例:CR 4例(25%),PR 8例(43.75%),SD 2例(12.50%),PD 2例(12.50%),RR为75%(12/16),DCR为81.25%(13/16),其中鼻咽癌的有效率达到100%。毒副作用主要为血液学毒副作用,以中性粒细胞减少为著。非血液学毒副作用中脱发(42.31%)、肝功能轻度损伤(30.77%)、口腔溃疡(26.92%)发生率较高。结论紫杉醇脂质体加顺铂方案结合同期放疗治疗恶性肿瘤疗效较好,副作用可以耐受。

Objective To evaluate the effectiveness and safety of paclitaxel liposomal plus cisplatin combined with radiotherapy for patients with malignant tumors. Methods Totally 26 patients with malignant tumors were treated by 2 - 4 cycles of chemotherapy of paclitaxel liposomes and cisplatin and received radiotherapy concurrently. Results Out of 26 patients, 16 patients achieved response, which included of complete response （n = 4, 25% ）, partial response （n = 8, 43. 75% ）, stable disease （n =2, 12. 50% ）, progress disease （n =2, 12. 5% ）. The overall response rate was 75% （12/16） （100% for nasopharyngeal cancer）. The main side reaction was haematological toxicity, notably neutropenia. Non-haematological toxicities included hair loss （42.31%）, mild liver damage （30.77%）, and oral ulcer （26. 92% ）. Conclusion The paclitaxel liposomes plus cisplatin combined with radiotherapy has good effectiveness in treating malignant tumors, and the side reactions can be well tolerated.