甲泼尼龙对急性肺损伤治疗作用的临床观察

Clinical Observation on Methylprednisolone in Treatment of Patients With Acute Lung Injury

目的:探讨早期应用低剂量甲泼尼龙对急性肺损伤(ALI)治疗的价值。方法:将43例ALI患者随机分为甲泼尼龙治疗组和常规治疗对照组,比较两组患者治疗前后的氧合指数变化和C反应蛋白浓度变化,并进行统计分析。结果:治疗组和对照组治疗后的氧合指数均有提高(P均<0.05)、C反应蛋白浓度均有下降(P均<0.05),治疗组的效果优于对照组(P<0.05)。结论:短期低剂量甲泼尼龙有抗炎作用,能协同常规治疗ALI患者的缺氧和休克,应用于合并感染性休克患者可为原发病治疗赢得时间与机会,同时减少因使用糖皮质激素而引起的副作用。

Objective：To explore the effects of low dose methylprednisolone in the early treatment of patients with acute lung injury （ALI）.Methods：Forty-three patients with ALI were divided into two groups：methylprednisolone treatment group and control group with conventional therapy.Changes of oxygenation index and C-reactive protein were compared and statistically analyzed before and after treatments.Results：The oxygenation index was improved and concentration of C-reactive protein was decreased after treatments in all the patients after therapy （P0.05）.The effect in methylprednisolone treatment group was better than that in control group （P0.05）.Conclusions：Short-term low dose methylprednisolone has an anti-inflammation effect which can treat hypoxia and shock in patients with ALI,and win the time for treatment in patients with septic shock,lessen the side-effect of glucocorticoid.