大黄对无创通气治疗慢性阻塞性肺病的影响

EFFECT OF RHUBARB ON TREATMENT OF NONINVASIVE POSITIVE PRESSURE VENTILATION ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE

目的:观察大黄对接受无创正压通气治疗慢性阻塞性肺病(COPD)患者的影响。方法:对照组在给予常规治疗的同时无创通气,治疗组加用大黄鼻饲;比较两组治疗前,治疗后8、24小时及3、7天时的动脉血气分析,并观察记录神志、呼吸、心率、呼吸困难等在各个治疗时期的变化。结果:治疗组患者均明显好转出院,对照组治疗后5例无改善而改用有创通气治疗,其余35例患者均好转出院;两组住院时间、机械通气时间、3、7天时呼吸困难计分比较差异有显著性(P<0.05,P<0.01);动脉血气分析结果治疗组明显优于对照组(P<0.05);面部压伤、感染等不良反应治疗组明显减少。结论:大黄对无创通气治疗COPD能明显缩短患者住院和机械通气时间,降低不良反应发生率。

Objective:To observe the effect of rhubarb on the curative effect of chronic obstructive pulmonary disease treated with noninvasive positive pressure ventilation.Methods:80 cases with chronic obstructive pulmonary disease complicated with respiratory failure were divided into two groups,40 cases of control group were given noninvasive positive pressure ventilation and conventional therapy,40 cases of treatment group were given rhubarb to intravenous infused on the basis of treatment of the control.The arterial blood gas values was determined before treatment and after treated 8 and 24 hours,3 and 7days,the consciousness,breath,heart rate and severity of dyspnea were observed and recorded during the treatment course.Results:All patients of treatment group were markedly improved and discharged from hospital,35 cases of control group were improved and discharged from hospital and the other 5 cases failed to be remitted and received the conventional invasive mechanical ventilation.There were obvious difference between the two groups on the duration of hospitalization and ventilation and the improvement of dyspnea,the results of arterial blood gas values in treatment group were better than those of the control.