摘要
目的:观察宣肺汤对B16黑素瘤细胞的作用,探讨其美白作用的机理及安全性。方法:测定宣肺汤对体外培养的B16黑素瘤细胞细胞活力、酪氨酸酶活性及细胞内黑素含量的影响,并与熊果苷作对照比较。结果:25、50、100μg/ml宣肺汤对黑素瘤细胞的细胞增殖、酪氨酸酶活性及黑素生成均有较强的抑制作用,并呈剂量依赖性,且优于同浓度熊果苷,差异均有统计学意义(P<0.05或P<0.01)。结论:宣肺汤有较强的抑制黑素瘤细胞增殖、酪氨酸酶活性和黑素生成的作用,同时对黑素瘤细胞的细胞毒性较低,是较为安全有效的美白药物。
Objective:To observe the effect of xuanfei decoction on B16 melaroma cells and discuss the mechanism of whitening function and safety.Methods:To determine the effects of xuanfei decoction on cytoactive and tyrosinase of B16 melaroma cells and melanin content,arbutin was taken as control.Results:Xuanfei decoction could inhibit the cellular proliferation,activity of tyrosinase and melanin formation of B16 melaroma cells,the effects were better than those of arbutin group,there was obviously difference between the two groups.
出处
《中国中医药科技》
CAS
2010年第2期102-103,共2页
Chinese Journal of Traditional Medical Science and Technology
基金
浙江中医药管理局资助项目No.2006C007
关键词
黑色素瘤/中医药疗法
@宣肺汤/治疗应用
体外研究
小鼠
Xuanfei decoction is a safe,effective medicine of whitening,inhibiting cellular proliferation,activity of tyrosinase and melanin formation of B16 melaroma cells was its part of mechanism.
