HBV与HEV重叠感染对肝纤维化指数的影响

The Effect of Superinfection of HBV and HEV on Liver Fibrosis

应用放免法检测慢性乙肝重叠戊肝病毒感染组，慢性乙肝组和急性戊肝组病人的血清透明质酸、Ⅲ型前胶原肽、Ⅳ型胶原，并与肝功能比较分析，结果显示重叠感染时肝功能损害严重，血清透明质酸、Ⅲ型前胶原肽随肝功能损害加重明显升高（Ｐ＜０．０５）。提示血清透明质酸、Ⅲ型前胶原肽既能反映肝功能的损害程度。

Hyalusonic acid,type Ⅲ procollagen peptide and type Ⅳ collagen in serm were measured by radioimmunoassay among the patients auffering from chronic hepatitis type B and superinfection of hepatitis type E virus.From chronic hepatis type B and acute hepatitis type E,comparisons with their liver functions were made.The results showed that liver functions were injured more seriously and hyalusonic acid and type Ⅲ procollagen peptide in serm were significantly higher( P <0.05)when the patients with chronic hepatitis type B were infected by hepatitis type Evirus.The findings suggested that hyalusonic acid and type Ⅲ procollagen peptide can reflect the injury of liver functions and occurrence of liver fibrosis.