WWOX在结直肠癌中的表达及其与Bax的相关性

Expression of WWOX in human colorectal carcinomas and its correlation with Bax

目的:探讨WWOX(WW domain containing oxidoreductase)基因的表达与结直肠癌生物学行为及Bax表达的相关性。方法:应用免疫组化EnVision二步法检测58例结直肠癌中WWOX和Bax的表达,并以20例结直肠炎症为对照。结果:WWOX、Bax在结直肠癌组织中的阳性率分别为25.86%、58.62%,显著低于结直肠炎症的65%、85%,差异有显著性;WWOX、Bax在结直肠癌中的表达与患者的预后相关,差异有显著性,且WWOX的表达在癌组织的浸润深度间差异有显著性;WWOX与Bax的表达呈正相关。结论:WWOX与Bax参与调控结直肠癌的发生、发展,而且两者协同作用,在结直肠癌的预后中扮演了重要角色。

Objective：To study the relationship between the expression of WWOX（WW domain containing oxidoreductase）and its biological behavior,as well as its correlation with the expression of Bax in colorectal carcinomas.Methods：The expressions of WWOX and Bax were detected by Envision immunohistochemical staining in 58 cases of colorectal carcinoma tissues,and compared with those in 20 cases of colorectal inflammatory.Result：The positive rates of WWOX,Bax were 25.86%,58.62% respectively in colorectal carcinomas,which were much lower than those（65%,85%）in colorectal inflammatory.There was significant difference between the two groups,The expression of WWOX,Bax in colorectal carcinomas tissues correlatied with the prognosis,and a significant difference of expression of WWOX in invasion in colorectal carcinomas was found,Expression of WWOX was positively correlated with Bax.Conclusions：WWOX and Bax correlate with occurrence and development of colorectal carcinoma.They play a key role in the prognosis of colorectal carcinoma.