布渣叶水提物解热退黄作用的实验研究

Experimental Study of Antipyretic and Jaundice-relieving Effect of Water Extract of Microcos paniculata

目的:研究布渣叶水提物的解热、退黄作用。方法:采用干酵母复制大鼠发热模型,α-萘异硫氰酸萘脂中毒诱导小鼠黄疸模型,观察布渣叶水提物的解热、退黄作用。结果:高、中剂量的布渣叶水提物对发热模型大鼠有显著降温作用;高、中、低剂量的布渣叶水提物能显著降低黄疸模型小鼠血清中总胆红素(T-Bil)与直接胆红素(D-Bil)的含量,并能显著抑制丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)活性。结论:布渣叶水提物具有一定的解热作用,并有良好的退黄与改善肝功能的作用。

OBJECTIVE： To study the antipyretic and jaundice-relieving action of water extract of Microcos paniculata. METHODS ： Dry yeast and α-naphthy isothiocyanate were applied to induce febrile model and jaundice model of mice, respectively to observe the antipyretic and jaundice-relieving effect of water extract of M. paniculata. RESULTS： High dose and middle dose of M. paniculata effectively inhibited the fervescence in febrile model rats. High-dose, medium-doses and low-dose of M. paniculata significantly reduced the content of T-Bil and D-Bil and inhibited the activities of ALP, AST and ALT. CONCLUSION： Water extract of M. paniculata had good antipyretic effect and obvious effect on jaundice and improvement of liver function.