中药注射剂致药源性水肿61例文献分析

Drug-induced Edema Caused by Traditional Chinese Medicine Injections:Literature Analysis of 61 Cases

目的:探讨中药注射剂致药源性水肿的规律及特点,为临床安全使用中药注射剂提供依据。方法:对1994～2007年国内公开报道的61例中药注射剂致药源性水肿病例进行统计分析。结果:中药注射剂致药源性水肿的发生无性别年龄差异;一般发生时间较短,30min内发生的病例有44例(占72.1%);出现的水肿类型以喉头水肿和眼部血管性水肿为多(分别占54.1%和34.4%);涉及23种中药注射剂,其中清开灵注射液、双黄连注射液、鱼腥草注射液等5种注射液更容易引起药源性水肿。结论:应加强中药注射剂临床使用的监测,促进中药注射剂临床安全使用。

OBJECTIVE： To discuss the general regularity and the characteristics of the drug-induced edema caused by traditional Chinese medicine injections （TCMI） so as to provide basis for rational drugs use in the clinic. METHODS： 61 cases of drug-induced edema caused by TCMI publicly reported in domestic journal from 1994 to 2007 were analyzed statistically. RESULTS： The drug-induced edema caused by TCMI was not linked to sex and age. The symptom appeared in a short period and edema was induced in 44 cases within 30 min （72.1%）. Laryngeal edema accounted for 54.1% and ocular angioedema 34.4%. 23 kinds of TCMI were involved, among which top 5 drugs in the list of incidence were Qingkailing injection, Shuanghuanglian injection, Yuxingcao injection, etc. CONCLUSION： Great importance should be attached to the monitoring of the clinical use of TCMI to promote the safety of TCMI.