摘要
目的:探讨中药注射剂致药源性水肿的规律及特点,为临床安全使用中药注射剂提供依据。方法:对1994~2007年国内公开报道的61例中药注射剂致药源性水肿病例进行统计分析。结果:中药注射剂致药源性水肿的发生无性别年龄差异;一般发生时间较短,30min内发生的病例有44例(占72.1%);出现的水肿类型以喉头水肿和眼部血管性水肿为多(分别占54.1%和34.4%);涉及23种中药注射剂,其中清开灵注射液、双黄连注射液、鱼腥草注射液等5种注射液更容易引起药源性水肿。结论:应加强中药注射剂临床使用的监测,促进中药注射剂临床安全使用。
OBJECTIVE: To discuss the general regularity and the characteristics of the drug-induced edema caused by traditional Chinese medicine injections (TCMI) so as to provide basis for rational drugs use in the clinic. METHODS: 61 cases of drug-induced edema caused by TCMI publicly reported in domestic journal from 1994 to 2007 were analyzed statistically. RESULTS: The drug-induced edema caused by TCMI was not linked to sex and age. The symptom appeared in a short period and edema was induced in 44 cases within 30 min (72.1%). Laryngeal edema accounted for 54.1% and ocular angioedema 34.4%. 23 kinds of TCMI were involved, among which top 5 drugs in the list of incidence were Qingkailing injection, Shuanghuanglian injection, Yuxingcao injection, etc. CONCLUSION: Great importance should be attached to the monitoring of the clinical use of TCMI to promote the safety of TCMI.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第11期1041-1042,共2页
China Pharmacy
关键词
中药注射剂
药源性水肿
药品不良反应
Traditional China medicine injections
Drug-induced diseases
ADR