雷公藤制剂抗蛋白尿疗效及其对肝脏、肾脏的影响

The Effect of Tripterygium Wilfordii Preparation in treatment of Proteinuria,Liver and Kidney

目的观察雷公藤制剂对阿霉素肾病大鼠蛋白尿的治疗作用及对肝脏、肾脏的影响。方法采用分次尾静脉注射阿霉素建立阿霉素肾病模型,将SPF级纯系SD大鼠分为正常组、模型组、雷公藤多苷组、雷公藤水提物组、雷至胶囊低剂量组、雷至胶囊中剂量组、雷至胶囊高剂量组,分别留取各组第0、2、3、4、5周尿标本,第5周末处死大鼠,检测大鼠白蛋白、甘油三酯、胆固醇及转氨酶含量;光镜、电镜观察肾组织病理形态学变化。结果模型组尿蛋白量逐渐增加,与模型组、雷公藤多苷组、雷公藤水提物组相比,雷至胶囊各剂量组第4、5周的尿蛋白均明显降低;模型组血白蛋白明显降低,甘油三酯、胆固醇明显升高,与模型组比较各治疗组白蛋白、甘油三酯、胆固醇均明显改善;雷公藤多苷组转氨酶水平明显高于其他组。结论从疗效或药物安全性方面雷至胶囊均优于其他雷公藤制剂,体现了减毒增效的效果。

Objective： To investigate the effect of Tripterygium Wilfordii preparation in treatment of proteinuria, and on liver and kidney in rats with adriamycin nephropathy. Methods： The SD rats were randomly divided into the model, tripterygium glycosides, Tripterygium Wilfordii extract, Leizhi Capsule low dose, Leizhi Capsule middle dose, Leizhi Capsule high dose and normal group. The urine samples were collected at 0, 2, 3, 4, 5th week after first adri- amycin injection respectively. At the end of 5th week, the rats were sacrificed. The renal tissue was acquired for the examinations of light microscopy, electron microscopy, and the blood was acquired for the examinations of albumin, triglycerides, cholesterol, and transaminase levels. Results： The model group amount of urinary protein was gradually increased. The Leizhi Capsule group amount of urinary protein at 4, 5th week are lower, compared with model group, tripterygium glycosides and Tripterygium Wilfordii extract group. Compared with model group, the treatment groups amount of albumin were increased while the treatment group amounts of triglycerides, cholesterol were de- creased. The transaminase level of tripterygium glycosides group was higher significantly than that of other groups. Conclusion： The effect of Leizhi Capsule was superior to other Tripterygium Wilfordii preparation from the efficacy or drug security side.