摘要
目的比较自行研制的可显影HA-P软腭植入材料与Pillar软腭植入材料(即PET)的纤维化效果。方法普通大白兔20只分为2组,第一组肌层内植入1根PET,另一组植入HA-P材料,于术后第7、15、30、60、90天2组分别处死实验动物2只,将埋植材料连同周围组织完整取出,制成标本并做石蜡切片行组织学检查,然后采用图像分析软件对纤维层厚度进行测量。结果两组材料纤维层厚度均随时间延长而增加,早期PET纤维化程度更好,术后90d实验组纤维层厚度为(16.7±4.4)μm,对照组为(17.9±4.1)μm,两组差异无统计学意义(P>0.05)。结论自行研制的可显影HA-P软腭植入材料与Pillar材料有相似的纤维化效果。
Objective To compare the fibrosis effects of polyethylene terephthalate（PET） and HA-P implants on the histologic structure of the palatal tissue in rabbit model.Methods Twenty rabbits were implanted PET and HA-P in muscle divided into 2 groups respectively.The animals were sacrificed after implantation at 7 days,15 days,30 days,60 days and 90 days,2 animals for each time.Specimens were collected for HE staining.Image Tool for Windows version 3.0 was applied to measure the thickness of capsule at different time intervals and the dynamic alteration in histology was observed.Results Histologic analysis demonstrated that thicker fibrosis developed in all specimens.At the beginning,more fibrosis was observed in PET.At the end of the experiment,the formation of capsule in PET implant ended up with a thickness of（17.9 ± 4.1） μm,slightly thicker than that of HA-P（16.7 ± 4.4） μm（P〉 0.05）.There were no obvious distinction between 2 groups.Conclusion It is demonstrated that PET and HA-P material stiffen the soft palate in same results.
出处
《生物医学工程与临床》
CAS
2010年第2期96-99,F0002,共5页
Biomedical Engineering and Clinical Medicine
基金
广东省自然科学基金重点项目(5000131)
