重组人表皮细胞生长因子对供皮区创面的修复

Reparation of skin donor site wound using recombinant human epidermal growth factor

背景:传统的供皮区创面修复以抗感染、支持及保护创面为主,最终为自然愈合,时间较长。研究表明,重组表皮生长因子促进皮肤切割、烧伤等动物模型创面的愈合,加速表皮再生的速度。目的:验证重组表皮生长因子对供皮区创面的修复效果。方法:选择泸州医学院附属医院整形烧伤科需要自体植皮修复创面的患者共32例,男18例,女14例。将32处新鲜供皮区创面随机均分为对照组和治疗组。治疗组将重组表皮生长因子药液(15mL/支,2000IU/mL)直接喷洒于单层内敷纱布上直至浸透,然后覆盖到供皮区,2次/d;对照组将单层生理盐水纱布覆盖供皮区,外加敷料包扎,2次/d。48h后,采用半暴露疗法。主要观察从治疗开始至供皮区完全愈合所需要的时间,不良事件及副反应,治疗前、后血常规及肝肾功能检测。结果与结论:在重组表皮生长因子喷洒组较生理盐水喷洒组明显缩短创面愈合时间,两组间比较具有显著差异(P<0.01)。重组表皮生长因子喷洒组未见明显的不良事件及副反应发生。提示经重组人表皮细胞生长因子处理后,能明显缩短创面的愈合时间,减少了瘢痕的过度增生,在加速创面愈合及再上皮化中具有显著的促进作用。

BACKGROUND：The traditional treatment for skin donor site wound was focus on anti-infection and wound protection,which took a long time for healing.Studies demonstrated that recombinant human epidermal growth factor（rhEGF） has accelerated effect on epidermal regeneration.OBJECTIVE：To observe the effect of rhEGF on wound healing of skin donor site.METHODS：A total of 32 cases needs wound healing by skin grafting were collected,including 18 males and 14 females.The 32 skin graft donor site wounds were randomly divided into control and treatment groups.In the treatment group,the absorbent gauze was sprinkle soaked with rhEGF（15 mL/ramus,2 000 IU/mL） and covered the donor site,twice per day.In the control group,donor site was covered by physiological saline gauze and wrapped with dressing,twice per day.After 48 hours,semi-exposed therapy was performed.The healing time of wounds,the systemic and local adverse reactions of patients and blood routine examination and renal function detection prior to and after treatment were observed.RESULTS AND CONCLUSION：The healing time of wound in the rhEGF treatment group was shorter than that in the control group with significant differences（P0.01）.No Adverse events or side effects were observed in the rhEGF treatment group.rhEGF can shorten wound healing time,reduce scar hyperplasia,and accelerate epithelization at the graft donor.