同一移植中心2年间亲属活体肾移植38例安全性评估

Evaluation of the safety of living-related donor kidney transplantation:A 38-case analysis within 2 years

背景:国内活体器官供者的安全性令人关注,供者移植后并发症,受者移植效果不理想或失败的病例有所发生。因此,必须重视活体肾移植,保证供者的生命安全和生活质量。目的:探讨亲属活体肾移植的安全性。方法:回顾性分析38对亲属活体肾移植供受者的临床资料,总结治疗经验。38例供者移植前明确身份,完善检查,充分告知治疗方案,合理手术。38例受者移植前充分透析,改善全身状况后行肾移植,移植后给予他克莫司或环孢素A、霉酚酸酯、皮质激素的三联基础免疫抑制方案治疗。观察肾移植后供受者肾功能变化、并发症发生率,以及受者急性排斥反应发生情况。结果与结论:亲属活体肾移植等待时间短、花费较少、长期存活率高的优势是明显的,供者的近期和远期风险都很小。尽管如此,进行亲属活体肾移植仍要充分评估供受者的风险,保证供受者的安全。

BACKGROUND：Security of organ donor attracts more attention,because donor complication and transplantation failure always occur following renal transplantation.Therefore,living-related kidney transplantation should be paid much attention in order to make sure life and quality of life.OBJECTIVE：To investigate the safety of living-related kidney transplantation.METHODS：A total of 38 cases of living relative donor kidney transplantation were retrospectively analyzed.Before transplantation,identify of patients should be determined,and all patients provided the informed consent.The general data of patients were sufficiently dialyzed before transplantation to improve the body status.Tacrolimus or mixture of cyclosporine A,mycophenolate,and adrenal cortex hormone were administrated following transplantation to observe renal function,complication incidence,and acute rejection reaction.RESULTS AND CONCLUSION：Due to short waiting time,low price,and long-term survival rate,living-relative donor kidney transplantation has low risk factors for donor.However,the safety still needs to be sufficiently evaluated for donors and recipients.