成骨因子在成骨及骨病中的作用

Role of osteogenic factors in bone disease and formation

背景:在骨形成及骨病中,有多种因子的表达,这些因子能在体外诱导软骨成骨,或诱导骨腹细胞成软骨细胞。目的:总结近年来广泛研究的成骨因子,强调成骨因子在骨形成和骨病中的作用。方法:以osteogenic factors,bone disease,bone formation,Intercellular Signaling Peptides and Proteins,osteogenesis为检索词,检索Medline数据库(2008-01/2009-07);以成骨因子,骨形成,骨病,细胞因子,刺激因子为检索词,检索中国期刊全文数据库(2008-01/2009-07)。文献检索语种限制为英文和中文。纳入成骨因子及骨形成或骨病相关的内容。排除已被证实落后的研究及重复性研究。结果与结论:计算机初检得到158篇文献,根据纳入排除标准,对成骨因子在骨形成和骨病中的作用进行分析。骨形成及骨病是复杂的过程,受多种激素、全身及局部生长因子的调控。多种骨生长因子参加了骨愈合与骨代谢相关疾病过程,通过局部自/旁分泌方式作用于靶细胞,也通过血液循环作用于远隔部位靶细胞。成纤维细胞生长因子,骨形成蛋白,血小板衍生生长因子,转化生长因子,白细胞介素1,胰岛素样生长因子,生长激素等都参与了骨重建过程中骨细胞的增殖、分化以及基质合成的调节及骨病的代谢。成骨因子在骨形成过程及骨相关疾病过程中发挥重要的作用,越来越多的成骨因子已用于临床及骨组织工程研究中,其效果已经得到了临床证实。

BACKGROUND： Many factors are expressed during bone formation and osteonosus, which can induce cartilage to transformed into bone, or induce periosteal cells to transform into chondrocytes. OBJECTIVE： To summarize the osteogenic factors in recent years, and explore the important roles of these factors in bone formation and osteonosus. METHODS： A computer-based online search of Medline database （2008-01/2009-07） and CNKI （2008-01/2009-07） was performed using the key words of ＂osteogenic factors, bone disease, bone formation, Intercellular Signaling Peptides and Proteins, osteogenesis＂ in English and ＂osteogenic factors, bone formation, bone disease, cytokine, stimulating factor＂ in Chinese. All the articles were limited to the English and Chinese languages. The content about the bone factors, bone formation or osteonosus was included. Repeated or old studies were excluded. RESULTS AND CONCLUSION： According to the exclusion criteria, 158 literatures were collected and the roles of osteogenic factors in bone formation and osteonosus were analyzed. Bone formation and osteonosus are complex processes, influenced by many hormones and systemic or local growth factors. A variety of bone growth factors participate in process of bone healing and bone metabolism-related disease, which act on the target cells through local autocrine/paracrine mode and influence the distant target cells through blood circulation mode. A great number of factors are involved in the process of bone cell proliferation, differentiation, matrix synthesis and osteonosus metabolism, such as the fibroblast growth factor, bone morphogenetic protein, platelet-derived growth factor, transforming growth factor, interleukin-1, insulin-like growth factor, growth hormone etc. Osteogenic factors play an important role in the process of bone formation and bone-related diseases. More and more factors have been used in clinical therapy and bone tissue engineering research, and their effects have been clinically proven.