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C型凝集素在结核病发病机制中的作用 被引量：3

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摘要 C型凝集素（C．type lectins）是一类非酶、非抗体蛋白质，其活性依赖于Ca2＋，以跨膜蛋白和水溶性蛋白两种形式存在。C型凝集素的共同结构特征是具有1个或多个糖识别域，能选择性识别并结合病原微生物的糖结构域。C型凝集素根据糖识别域1级结构的不同可分为蛋白聚糖、Ⅰ型跨膜受体、Ⅱ型跨膜受体、胶原凝集素、选凝素及自然杀伤细胞受体6个家族，其中胶原凝集素、Ⅰ型跨膜受体和Ⅱ型跨膜受体与结核病的发病机制密切相关。
作者 王建军 郭述良 罗永艾
机构地区 重庆医科大学附属第一医院呼吸科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2010年第3期214-216,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 国家自然科学基金资助项目（30571653） 重庆市卫生局资助项目（05-2-113）
关键词 C型凝集素 发病机制 结核病 自然杀伤细胞受体 胶原凝集素 跨膜受体 糖识别域 结构特征
分类号 R52 [医药卫生—内科学]
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参考文献21

  • 1Gold JA, Hoshino Y, Tanaka N, et al. Surfactant protein A modulates the inflammatory response in macrophages during tuberculosis. Infect Immun, 2004, 72:645-650.
  • 2Tones JB, Azad AK, Henning LN, et al. Role of C-type lectins in mycobacterial infections. Curr Drug Targets, 2008, 9 : 102-112.
  • 3Lopez JP, Clark E, Shepherd VL. Surfactant protein A enhances Mycobacterium avium ingestion but not killing by rat macrophages. J Leukoc Biol, 2003, 74:523-530.
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二级参考文献31

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共引文献13

同被引文献33

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二级引证文献11

中华结核和呼吸杂志
2010年 第3期

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