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我们可以从TORCH研究中学到什么? 被引量:1

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摘要 TORCH(towards a revolution in COPD health)研究是一项国际间合作的多中心、随机、双盲、安慰剂对照、平行设计的临床研究,最初募集的COPD患者达8554例。尽管长效β2-受体激动剂(LABA)和吸人皮质醇激素(ICS)联合疗法已广泛应用于COPD的治疗,但未能显示出这一疗法对患者病死率的影响。
作者 施焕中
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2010年第3期239-240,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
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  • 1Calverley PM, Anderson JA, Celli B, et al. on behalf of the TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med, 2007, 356: 775-789.
  • 2Vestbo J, The TORCH Study Group. The TORCH ( TOwards a Revolution in COPD Health) Survival Study protocol. Eur Respir J, 2004, 24: 206-210.
  • 3Keene ON, Vestbo J, Anderson JA, et al. Methods for therapeutic trials in COPD: lessons from the TORCH trial. Eur Respir J, 2009, 34: 1018-1023.
  • 4MeGareey LP, John M, Anderson JA, et al. Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee. Thorax, 2007, 62: 411-415.
  • 5Jenkins CR, Jones PW, Calverley PM, et al. Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study. Respir Res, 2009, 10:59.
  • 6Johnson M, Agusti AG, Barnes NC, Reflections on TORCH: potential mechanisms for the survival benefit of salmeterol/ fluticasone propionate in COPD patients. COPD, 2008, 5: 369- 375.
  • 7Celli BR, Thomas NE, Anderson JA, et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease, results from the TORCH study. Am J Respir Crit Care Med, 2008, 178 : 332-338.
  • 8Crim C, Calverley PMA, Anderson JA, et al. Pneumonia risk in COPD patients receiving inhaled eorticosteroids alone or in combination : TORCH study results. Eur Respir J, 2009, 34 : 641-647.
  • 9Ferguson GT, Calverley PMA, Anderson JA, et al. Prevalence and progression of osteoporosis in patients with COPD : results from TORCH. Chest, doi:10. 1378/chest. 08-3016.
  • 10Briggs A, Glick H, Lozano-Ortega G, et al. Is treatment with ICS and LABA cost-effective for COPD? Multinational economic analysis of the TORCH study. Eur Respir J, 2009, Inpress.

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