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FIP1L1/PDGFRA阳性的慢性嗜酸性粒细胞白血病一例 被引量:2

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摘要 患者男,26岁,主因心悸1年,面色苍白5个月于2009年1月入院。患者于1年前无明显诱因出现心悸,偶有心前区疼痛和活动后喘憋。5个月前患者出现面色苍白,伴头晕、乏力。当地医院血常规:白细胞10.66×10^9/L,血红蛋白81g/L,血小板189×10^9/L,嗜酸性粒细胞比例63.7%。既往体健,无哮喘病史,无疫区接触史,无类似家族病史。
出处 《中华医学杂志》 CAS CSCD 北大核心 2010年第8期563-563,共1页 National Medical Journal of China
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同被引文献30

  • 1李斌,张广森,戴崇文,裴敏飞.高嗜酸性粒细胞综合征患者粒细胞JAK/STAT信号转导途径的激活及对甲磺酸伊马替尼的治疗反应[J].中华医学杂志,2005,85(7):448-452. 被引量:8
  • 2Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1 L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med, 2003,348 : 1201-1214.
  • 3Helbig G, Moskwa A, Hus M, et al. Clinical characteristics of patients with chronic eosinophilic leukaemia (CEL) harbouring FIP1L1-PDGFRA fusion transcript--results of Polish multicentre study. Hematol Oncol, 2010,28 : 93-97.
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  • 7Menezes J, Acquadro F, Perez-Pons de la Villa C, et al. FIP1L1/ RARA with breakpoint at FIP1 L1 intron 13 : a variant translocation in acute promyelocytic leukemia. Haematologica, 2011,96 : 1565- 1566.
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  • 10Fukushima K, Matsumura I, Ezoe S, et al. FIP1L1-PDGFRtx imposes eosinophil lineage commitment on hematopoietic stem/ progenitor cells. J Biol Chem, 2009,284 : 7719-7732.

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