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皮肤恶性肿瘤的DNA异常甲基化研究进展 被引量：2

Advances in Aberrant DNA Methylation in Cutaneous Malignancies
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摘要 对肿瘤研究的不断深入发现除了基因突变之外,表观遗传改变也与肿瘤的发生发展密切相关。肿瘤表观遗传的改变以DNA的异常甲基化为主,其主要的机制是由肿瘤抑制基因启动子超甲基化引起基因沉默。DNA的异常甲基化几乎存在于任何类型的人类肿瘤中,包括皮肤恶性肿瘤。现对DNA甲基化、DNA甲基化与肿瘤、DNA甲基化在基底细胞癌、鳞状细胞癌、黑色素瘤和皮肤淋巴瘤等皮肤恶性肿瘤中的研究进行综述。 A growing evidence suggests that in addition to gene mutations,epigenetic alterations are also closely related with the development and progression of tumors. Tumor epigenetic alterations are presented as aberrant DNA methylation and the major mechanism is tumor-suppressor gene promoter hypermethylation induces gene silencing. Aberrant DNA methylation occurs in almost all kinds of human tumors,including cutaneous malignancies. In this review,we summarize the current knowledge of DNA methylation associated with tumorigenesis and advances in DNA methylation in basal cell carcinoma,squamous cell carcinoma,melanoma and cutaneous lymphoma.
作者 陈办成 万峻
机构地区 北京大学深圳医院皮肤科 北京大学香港科技大学医学中心生物医学研究所
出处 《皮肤性病诊疗学杂志》 2010年第1期78-80,共3页 Journal of Diagnosis and Therapy on Dermato-venereology
关键词 DNA甲基化 表观遗传 基底细胞癌 鳞状细胞癌 黑色素瘤 皮肤淋巴瘤 DNA methylation epigenetic carcinoma basal cell carcinoma squamous cell melanoma cutaneous lymphoma
分类号 R739.5 [医药卫生—肿瘤]
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参考文献20

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同被引文献47

  • 1Ally MS, Robson A. A review of the solitary cutaneous T-cell lymphomas[J]. J Cutan Pathol, 2014, 41(9): 703-714.
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  • 5Jones CL, Ferreira S, Mckenzie RC, et al. Regulation of T-plas- tin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma[J]. J Invest Dermatol, 2012, 132(8): 2042-2049.
  • 6Contassot E, French LE. Epigenetic causes of apoptosis resis- tance in cutaneous T-cell lymphomas [J]. J Invest Dermatol, 2010, 130(4): 922-924.
  • 7Ferrara G, Pancione M, Votino C, et al. A specific DNA methy- lation profile correlates with a high risk of disease progression in stage I classical(Alibert-Bazin type) mycosis fungoides[J]. Br J Dermatol, 2014, 170(6): 1266-1275.
  • 8Subramaniam D, Thombre R, Dhar A, et al. DNA methyltrans- ferases: a novel target for prevention and therapy[J]. Front On- col, 2014, 4: 80.
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  • 10Wu J, Wood GS. Reduction of Fas/CD95 promoter methylation, upregulation of Fas protein, and enhancement of sensitivity to apoptosis in cutaneous T-cell lymphoma[J]. Arch Dermatol, 2011, 147(4): 443-449.

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皮肤性病诊疗学杂志
2010年 第1期

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