肾素瘤的诊断和治疗(附3例报告)

The diagnosis and treatment of reninoma(report of 3 cases)

目的提高肾素瘤的诊治和治疗水平。方法回顾分析3例肾素瘤患者的临床资料,结合文献复习进行讨论。3例患者均表现有高血压、高肾素和高醛固酮血症。2例临床表现有低血钾。结果2例患者行保留肾单位的肾肿瘤切除术,1例行肾切除术,术后病理示:肾素瘤。3例患者术后血压、血浆肾素、醛固酮和血钾等恢复正常,随访3～12年未见肿瘤复发及高血压再发。结论肾素瘤为罕见的良性肾脏肿瘤,肿瘤根治性切除效果满意,预后良好。

Objective To improve the diagnosis and treatment of reninoma. Methods We compared the data of 3 cases of reninoma and reviewed the literature. Results All patients had hypertension and high levels of peripheral serum renin activity and hyperaldosteronism. 2 of them had hypokalemia. Partial nephrectomy was performed in 2 patients and total nephrectomy in 1 patient. Post-operative histopathological study revealed reninoma. The hypertension, peripheral serum renin activity, hyperaldosteronism and hypokalemia returned normal after tumor resection. During a mean follow-up of 84 months （range 36 to 144 months ）, no tumor recurrence and hypertension were documented. Conclusions Reninoma is a benign tumor of kidney, which can be satisfactorily cured with tumor resection.