穿透性角膜移植排斥反应危险因素分析

Investigation about the risk factors of the graft rejection after penetrating keratoplasty

目的:探讨穿透性角膜移植术后植片排斥的危险因素。方法:回顾性分析我院2001-01/2008-01实施穿透性角膜移植发生排斥反应的病例,分析各因素在植片排斥反应病例中所占的比率及各种病例中植片排斥的发生率。结果:总排斥反应率为31.0%,其中普通组为25.5%,高危组为59.4%(P<0.05)。眼部化学伤排斥反应发生率最高48.1%(P<0.05)。高危组发生排斥反应早且病情严重。结论:引起角膜植片排斥的多种因素中,不同疾病的穿透性角膜移植的发生率不同,排斥反应的发生与术前原发病,植床情况,手术设计操作术后预防有密切关系,其中植床新生血管是植片排斥的高危因素。

AIM： To investigate the risk factors of corneal graft rejection after penetrating keratoplasty. METHODS： The rejection cases of penetrating keratoplasty in our hospital from 2001-01 to 2008-01 were retros-pectively analyzed, the ratio of various factors in the graft rejection patients and the incidence of graft rejection in all kinds of cases were analyzed. RESULTS： The total rejection rate was 31.0%, 25.5% in normal group, 59.4% in high-risk group （P〈 0.05）, 48.1% in chemical eye burn group （P〈0.05）. Rejection of high-risk group was early and serious. CONCLUSION ： Of the factors of corneal graft rejection, the rejection rate is different in different original diseases, the graft rejectim has a close relationship with the preoperative symptoms, planting beds, surgical operation design and the prevention after surgery. Planting beds neovascularization is a high risk factor of graft rejection.