冻土毛霉所致的原发性皮肤毛霉病

Primary Cutaneous Mucormycosis Caused by Mucor Hiemalis F.Luteus

目的报道一例罕见的由冻上毛霉黄色(或上黄)变种所致的原发性皮肤毛霉病。方法取患者面部焦痂下脓性分泌物直接镜检及培养,取面部活检组织部分行组织病理,部分做真菌培养结果直接镜检可见粗的、无分隔的、成直角分支的菌丝,活检组织切片,HE 染色示:肉芽肿样改变,并可见特征性的、宽的、无分隔的菌丝、PAS(+);脓性分泌物及活检部分组织25℃ SDA 培养3天后,可见黄色的菌落,37℃不生长、菌种鉴定为:冻土毛毒黄色(或上黄)

Objective Wereport a rare ease of primarv cutaneous mucormvcosis,caused by muc hiemalisf.lulens(Linnemann)schipper.methods(1)VIcrsexamination,of KOH preparation and culof purulent seeretion under the eachar from the face.(2)bionsy frome skin lesion was also, taken for pathologic examinattion,and culture.Results and Conclusion(I)Mieromseopicamination showed characteristic thick,nonseplate right-angled branched hyphae.(2)H.E stain of biopsy specimen reveled granulomatous change and characleristic broad,nonseplate hyphae which was PAS(+).(3)Yellow colonies were observed,on the culurs,of purulent secrelion and biopay specinmen with SDA media at 25℃ for 3 days. but no growth at 37℃.and the fugus was identilied as M. hiemulisf. luteus( linnemunn)Schipper. Treat- ment,of the patient with sporano(ltraconazole)was successful.