双环醇联合拉米夫定治疗慢性乙型肝炎临床观察

Clinical observation of Bicyclic Alcohol unites Lamivudine in Treatment of Chronic Hepatitis B

目的观察双环醇联合拉米夫定治疗慢性乙型肝炎的治疗效果。方法180例慢性乙型肝炎患者随机分为三组。双环醇组用双环醇(北京协和药厂)口服25mg/次,3次/d,疗程6个月;拉米夫定组用拉米夫定100mg口服,每日1次,疗程6个月,联合组双环醇和拉米夫定同时应用。结果治疗结束时,联合组肝功复常率与双环醇组相近,高于拉米夫定组;HBVDNA阴转率联合组76.7%与拉米夫定组70.0%相近,高于双环醇组28.3%;HBeAg阴转率联合组43.3%高于双环醇组25.0%及拉米夫定组11.7%。结论双环醇联合拉米夫定治疗慢性乙型肝炎有协同作用,优于单一用药。

Objective To observe the effect of bicyclic alcohol combined with lamivudine on treatment of chronic hepatitis B treatment.Methods Total 180 patients with chronic hepatitis B were randomly divided into three groups.Bicyclol group with bicyclic alcohol（Beijing Union pharmaceutical） oral administration of 25mg/times,3 times/d,treatment for 6 months;lamivudine group received oral lamivudine 100mg daily 1 times,course of treatment 6 month,alcohol and lamivudine combination group at the same time applications.Results The end of treatment,the Joint Group liver function normalization rates were similar with that of bicyclic alcohol group（P0.05）,higher than the lamivudine group（P0.01）;HBVDNA negative rate of 76.7% and the combination group Lamivudine group of 70.0% is similar（P0.05）,higher than that of bicyclol group 28.3%（P0.01）;HBeAg negative rate 43.3% higher than the combination group Bicyclol group 25.0%（P0.05） and Lamivudine group 11.7%（P0.01）.Conclusion Bicyclol lamivudine treatment of chronic hepatitis B has synergistic effect and better than a single medication.