抑凋亡基因Bcl-X在鼻息肉中表达的初步研究

APOPTOTIC INHIBITOR Bcl-X PROTEIN EXPRESSION IN NASAL POLYP

目的：探讨细胞凋亡基因Ｂｃｌ－２，Ｂｃｌ－Ｘ，Ｂａｋ和Ｂａｘ蛋白在鼻息肉中的表达及意义。方法：应用免疫组织化学方法（ＡＰＡＡＰ法）检测Ｂｃｌ－２，Ｂｃｌ－Ｘ，Ｂａｋ和Ｂａｘ蛋白在６例鼻息肉中的表达。结果：６例鼻息肉上皮Ｂｃｌ－Ｘ均呈强阳性表达，３例（３／６）Ｂｃｌ－２阳性表达，２例（２／６）Ｂａｋ弱阳性表达，１例（１／６）Ｂａｘ阳性表达。

Objective:To investigate the apoptosis in nasal polyp by detection of the expression of 4 apoptosis related proteins Bcl 2,Bcl X,Bak and Bax.Methods:Bcl 2,Bcl X,Bak and Bax were investigated in 6 nasal polyps by immunohistochemistry (APAAP).Results: 6/6 of Bcl X and 3/6 of Bcl 2 were expressed middle/strongly in the epithelium of nasal polyp.In contrast,only 2/6 of Bak and 1/6 of Bax were found weakly stained in the epithelium of nasal polyp.Conclusion:Up regulated apoptotic inhibitor Bcl X and down regulated apoptotic promotors Bak and Bax might be associated with the genesis and development of nasal polyp.