增殖细胞核抗原在喉粘膜不典型增生及喉癌组织中表达的意义
被引量:1
摘要
目的:研究增殖细胞核抗原在喉粘膜不典型增生及喉癌组织中的表达。方法:采用免疫组化LSAB法,用抗增殖细胞核抗原(PCNA)的单克隆抗体对9例正常喉粘膜、29例喉粘膜不典型增生及36例喉鳞状细胞癌进行标记及分析。结果:随着喉粘膜病变的加重,PCNA的标记指数(LI)有逐渐增高的趋势。而LI与喉鳞状细胞癌的病理分级、T分期、淋巴结转移及肿瘤生长部位均无关。结论:PCNA对喉鳞状细胞癌的早期诊断有重要意义,在指导临床治疗上也有重要的参考价值。
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
1998年第4期243-245,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
参考文献6
-
1Garicia PL,Coltrera MD,Grown AM,Rapid communication,analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodied in fixed,embedded tissues,AM J Pathol,1989,134:733.
-
2Bravo R,Frank R,Blundell PA,et al.Cyclin/PCNA is the anxiliary protein of DNA polymerase-δ.Nature,1987,326:515.
-
3Garmen CWY,Christopher DMF,Paul LN,et al.A comparision of proliferation cell nuclear antigen(PCNA)immunostaining,nuclear oganizer region(AgNOR)staining,and histological grading in gastrointestinal stromal tumors,J Pathol,1992,166:147.
-
4Nakano H,Namatame K,Nadayoshi A,et al.The evaluation of cellular proliferating activity in gastric carcinoma with PCNA expressive rate:its foundmental examination of the immunohistochemical procedures and its clinical application.Nippon Gakkai Zasshi,1993,94:580.
-
5Jains DA,Fillipe MI,Hall PA,et al.Prognostic value of proliferating cell nuclear antigen in gastric carcinoma.J Clin Pathol,1991,44:655.
-
6Siitonen SM,Isda JJ,Rantala IS,et al.Intratumor variation in cell proliferation in breast carcinoma as determined by antiproliferating cell nuclear antibody and automated image analysis.Am J Pathol,1993,99:226.
同被引文献10
-
1Suzuk H, Matsumoto K,Terabe M. Ki-67 antibody labeling index in clorectalcarcinoma[J]. J Clin Castroenterol,1992;15(3) :317- 320.
-
2Kyzer S, Gordon PH. Determination of proliferative activity in colorectal carcinoma using monoclonal antibody Ki - 67 [J]. Dis Colon Rectum, 1997:40(3) :322 - 325.
-
3Zheng X, Hu L, Chen F, et al. Expression of Ki - 67 antigen,epidermal growth factor recept Epstein- Ban- virus- encoded latent membrane protein(Lmpl) nasopharyn4geal carcinoma[J]. Eur J Cancer Boral Oncol, 1994;30B(5) :290 - 295.
-
4Holt PR. Is Ki - 67 a better proliferative marker in colon than proliferating cell nuclear antigen[J]? Cancer Epider moil Biomarkers Prev, 1997; 6 (2) : 131.
-
5Sarac S,Ayhan A, Hosal S, et al. Prognostic significance of PCNA expression in laryngeal cancer[J ]. Arch Otolaryngol Head Neck Surg, 1998; 124(2): 1321 - 1324.
-
6Wang CC, ChanKC, LeeKC, et al.Differential expression of P16/P21/P27 and CyclinD1/133 and their relationships to cell proliferation,apoptosis and tumor progression in invasive ductal carcinoma of the breast[J ]. J Pathol,2001 ; 194(1) :35 - 42.
-
7向明亮,吴韵芳,王纾宜.喉非典型增生和鳞癌的PCNA、p21表达及其意义[J].中国耳鼻咽喉颅底外科杂志,1998,4(3):148-150. 被引量:1
-
8董频.p53基因表达、细胞增殖抗原Ki-67与下咽癌关系的探讨[J].山东医大基础医学院学报,2000,14(6):324-326. 被引量:4
-
9刘坤平,冯伟勋,谢芝香.大肠癌CDK4、Ki-67表达与Cyclin D1、p16蛋白表达的相关性及临床意义[J].中国肿瘤临床与康复,2001,8(4):9-11. 被引量:4
-
10姜福金,孙晓青,郑骏年,蒋家骏,周齐军,马松.细胞增殖核抗原Ki-67在肾癌组织中的表达及意义[J].徐州医学院学报,2001,21(5):361-362. 被引量:8
-
1孙威,王强,王明德,秦晔,张凤祥,于文泉.人抗增殖细胞核抗原Ki-67和增殖细胞核抗原在消化道平滑肌肿瘤中的表达及其相互关系[J].中华医学杂志,1999,79(11):840-841. 被引量:1
-
2姜彦多,贾兰玲,王永信,关婷,张乃连.增殖细胞核抗原对卵巢癌生物学行为和预后判断的意义[J].沈阳部队医药,1996,9(6):513-515.
-
3王昌明,曾锦荣,陈梅晞,蒋述科,任格,林武洲.肺癌中增殖细胞核抗原表达的意义[J].临床内科杂志,2000,17(2):107-108. 被引量:3
-
4谢青,肖桃元,高广正,张敏,徐飞,王亚莉.肺癌放疗或化疗后的病理形态及PCNA、p53表达的观察[J].第三军医大学学报,1996,18(4):316-319. 被引量:3
-
5曹志伟,任重,王琰.增殖细胞核抗原与喉癌恶性度的关系[J].中国医科大学学报,1997,26(6):609-611. 被引量:4
-
6徐燕杰,王政民.抗增殖细胞核抗原/周期素在甲状腺癌中的表达[J].中华外科杂志,1993,31(10):628-629.
-
7石灵春,吴万垠,张维彬,区勇全,谭敏,肖楚梅.莪术油对小鼠肝癌增殖细胞核抗原的影响[J].世界华人消化杂志,1999,7(2):156-157. 被引量:26
-
8乔并生,吴奇光,武登诚.口腔鳞状细胞癌增殖细胞核抗原的研究[J].中华口腔医学杂志,1995,30(1):21-22. 被引量:4
-
9王业华,姜英,陈刚,顾沈阳.前列腺癌增殖细胞核抗原(PCNA)的研究[J].现代泌尿外科杂志,1998,3(2):97-99.
-
10郑唯强,詹洲,倪灿荣,龚志锦,刘伟强.乳腺癌增殖细胞核抗原同AgNoR和病理学特性的关系[J].实用癌症杂志,1994,9(1):5-7. 被引量:6