角膜胶原膜的研制及临床应用

The trituration of corneal collagen shield and clinical application.

研究角膜胶原膜的制做方法及其在单纯疱疹病毒性角膜炎（ＨＳＫ）治疗中的应用。从猪巩膜中提取胶原采用离心干燥成膜法制成角膜胶原膜，在无环鸟苷药液内浸泡后用于治疗单纯疱疹病毒性角膜炎。结果应用浸泡无环鸟苷（ＡＣＶ）药液的胶原膜治疗组病灶平均愈合时间为９．４５天，局部滴无环鸟苷药液组病灶愈合平均时间为１４．３６天，两组治愈率和有效率分别为９０．６３％、６５．６３％和９６．８８％，８１．２５％差异显著（ｐ＜０．０５）。可见浸泡无环鸟苷药液后的胶原膜在单纯疱疹病毒性角膜炎的治疗中将具有较好的应用前景。

Study the method of making corneal collagen shield and the therapeutic results of treating Herpes Simplex Keratitis(HSK)clinically.Collagen was extracted from sclera of pig.Using centrifugal method to make corneal collagen shield.After soaked with Aciclovir(ACV)the corneal collagen shields were used for treating HSK.The results indicate that in the group of corneal collagen shield soaked with ACV the average recover time of cornea was 9 45 days,in the group of instillation of ACV eye drops the average recover time was 14 36 days.The cure rate and effective rate of the two groups were 90 63%、65 63% and 96 88%、81 25%(P<0 05).Conclusions:The corneal collagen shield immersed with ACV will play an important role in HSK treatment.