小剂量阿司匹林防治Ⅱ型糖尿病患者视网膜病变的临床研究

Clinical study on the prevention and treatment of NttiDM retinopathy with small dose aspirin

为探讨糖尿病视网膜病变的防治方法，对106例患Ⅱ型糖尿病（NIDDM）但尚未出现明显视网膜病变者，在血糖水平基本控制稳定的情况下，随机抽取53例，日服小剂量阿司匹林（40－80mg／d），坚持服药2a后，观察两组病人眼底病变的发生和改变。结果表明，小剂量阿司匹林组较之对照组的视网膜病变的发生率低且程度轻，二者之间有显著差别（X2＝6．09，P＜0．05）。并对小剂量阿司匹林防治糖尿病微血管病变的临床作用机制进行探讨。提示：小剂量阿司匹林不失为防治Ⅱ型糖尿病早期视网膜病变的药物经济学意义。

In order to explore the method of preventing and treating NIDDM retinopathy. We gave small dose aspirin(40 - 80mg/d)to 53 cases selected at random from 106 cases with NIDDM, but without obvious retinopathy when their blood sugar level was basically stable. And we observed the development and changes of eyeground pathological process after continuous administration of two years. the results show that the incidence of retinopathy under small dose Aspirin is lower than the control and the pathological degree is milder (X2 = 6. 09, P < 0. 05). We also explored clinical functional mechanism of small dose aspirin in preventing and treating NIDDM microangiopathy. The results suggest that small dose Aspirin is effective and economic in preventing and treating NIDDM retinopathy at the early stage.