甲钴胺片联合养阴活血汤治疗糖尿病周围神经病变72例的疗效观察

Observation on the treatment diabetic peripheral neuropathy with methylcobalamin and Chinese medicines of nourishing Yin and promoting blood circulation

目的 观察甲钴胺片联合自拟养阴活血汤治疗糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）的临床疗效。方法将72例DPN患者随机均分为治疗组和对照组，比较两组治疗前后症状、神经传导速度、血常规、血生化全项、心电图的变化。结果治疗组总有效率为88．0％，对照组总有效率为68．2％，两组总有效率比较，差异有统计学意义（t=3，14，P〈0．01），两组治疗前后血常规、血生化全项（除血糖水平外）、心电图均无明显变化。结论甲钴胺片联合养阴活血汤治疗DPN效果较好。

Objective To observe the effect of treating diabetic peripheral neuropathy （DPN） with methylcobalamin and Chinese medicines with the functions of nourishing Yin and promoting blood circulation. Methods 72 patients with DPN were randomly recruited into a control group and a treatment group. Symptoms, NCV, value of blood routine examination, blood biochemistry check and ECG were compared before and after the treatment. Results The total effective rate was 88.0% and 68.2% in the treatment group and the control group respectively, showing significant difference （t=3.14, P〈0.01 ） . The value of blood routine examination, blood biochemistry check （except blood sugar level）and ECG showed no obvious changes before and after the treatment in both groups. Conclusion Therapy of methylcobalamin Tablets with Chinese medicines of nourishing Yin and promoting blood circulation is effective on DPN and worth of clinical promotion.