莲草口服液的质量标准控制方法探讨

Study on quality standard of Liancao Oral Liquid

目的 建立莲草口服液的质量标准。方法采用高效液相色谱法对莲草口服液中的主要成分野黄芩苷、对香豆酸进行含量测定。结果野黄芩苷进样量在0．208～1．042μg范围内与峰面积线性关系良好，（r=09999）（n=5），平均回收率为100．3％，RSD=081％（n=6）；对香豆酸进样量在0．079-0．394μg范围内与峰面积线性关系良好，（r=0．9994）（n=5），平均回收率为99．6％，RSD=0．94％（n=6）。结论建立了莲草口服液的含量测定方法。该方法精确，重现性好，操作简便，可作为莲草口服液质最控制标准。

Objective To establish the quality standard of Liancao Oral Liquid. Methods The content of scutellarin and p-Coumaric acid in Liancao Oral Liquid was determined by HPLC. Results There was a good linearity for scutellarin in the range of0.208-1.042μg （r=0.9999） （n=5） , The average recovery rate was 100.3%, RSD：0.81% （n = 6 ） ; There was a good linearity for p-Coumaric acid in the range of 0.079-0.394 μg （r=0.9994 ） （n= 5 ） , The average recovery rate was 99.6%, RSD： 0.94% （n= 6） . Conclusion To develop a method of determining the content of Liancao Oral Liquid. The methods are simple, effective with good reproducibility, which can be used for the quality control of Liancao Oral Liquid.