摘要
目的研究贝那普利联合氯沙坦对慢性心力衰竭患者核因子-κB(NF-κB)和高敏C-反应蛋白(hs-CRP)的影响。方法40例慢性心力衰竭患者随机分为贝那普利组和贝那普利联合氯沙坦组。采用超声心动图测左室射血分数(LVEF);免疫细胞化学法测定外周血淋巴细胞NF-κB活化的阳性率;ELISA法测定血浆hs-CRP水平,比较两组治疗前后的差异。结果治疗3个月后,贝那普利组LVEF低于联合治疗组(P<0.05);贝那普利组NF-κB活化的阳性率及hs-CRP水平高于联合治疗组(P<0.05)。结论贝那普利联合氯沙坦治疗慢性心力衰竭患者在改善心功能,降低外周血淋巴细胞NF-κB活化的阳性率和血浆hs-CRP水平方面优于单用贝那普利。
Objective To investigate the effect of benazepril combined with losartan on nuclear factor-κB （NF-kB） and high-sensitivity C-reactive protein（hs-CRP）in chronic heart failure（CHF）. Methods We divided 40 cases of CHF randomly into benazepril group（n =20） and benazepril plus losartan group（n = 20 ）, measured the left ventricular eject fraction by using echocardiogram, the positive rate of the NF- κ B activation in peripheral blood lymocytes by immunohistochemical method and the level of plasma hs-CRP by the enzyme-linked immunosorbant assay and compared the differences of effects before and after treatment in both groups. Results After three-month treatment,the left ventricular eject fraction of the benazepril group was lower than that of the benazepril plus losartan group（P〈0.05）,but the positive rate of the NF-κ B activation and the hs-CRP level in the the benazepril group were significantly elevated compared with the benazepril plus losartan group（P〈0.05 ）. Conclusion Application of benazepril combined with losartan in the treatment of CHF is better than application of be- nazepril alone, and the former can ameliorate the heat function and decrease the positive rate of the NF- κB activation and in peripheral blood lymocytes and the plasma hs-CRP level in the patients with CHF.
出处
《中国现代医生》
2010年第9期3-4,共2页
China Modern Doctor
