国产氯吡格雷治疗不稳定型心绞痛临床疗效观察

Clinical effect of clopidogrel in patients with unstable angina pectoris

目的探讨国产氯吡格雷在不稳定型心绞痛患者中的临床疗效。方法选2005年9月至2009年8月102例不稳定型心绞痛患者,随机分入常规口服药物治疗组(A组,51例)和国产氯吡格雷组(B组,51例)。B组在常规口服药物的基础上加国产氯吡格雷75 mg,1次/d,持续4周。在入组前以及服药每周内门诊随访,共4周,询问病史,不良反应以及行活动平板检查。结果102例患者全部完成随访。4周内,B组胸痛发作每周次数减少(4.2±0.5)次,而A组减少(2.1±0.8)次,两组相比有统计学差异(P<0.05)。硝酸甘油消耗量B组平均减少(6.1±0.7)片而A组平均减少(3.3±0.9)片(P<0.05)。运动平板运动持续时间B组增加(63.6±2.3)s而A组增加(31.6±2.2)s(P<0.05)。结论在传统药物治疗的基础上联用国产氯吡格雷,可以使不稳定型心绞痛患者受益,且安全性好。

Objective To evaluate the therapeutic efficacy of clopidogrel in patients with unstable angina pectoris.Methods A total of 102 patients with unstable angina pectoris were divided into two groups randomly：traditional medition therapy group（A）and clopidogrel therapy group（B）from September 2002 to August 2005.Patients in B group were received a stabilization,4 week therapy with clopidogrel 50 mg daily.Some clinical data such as patient,s history,side reactions and treadmill exercises tests results were collected before taking medicine and 4 weeks later.Results All patients were completed the follow-up.During the follow-up,the times of the anginal attacks in every week dereased by 4.2±0.5 in B group,but 2.1±0.8 in A group（P0.05）;the consumption of nitroglycerine pills reduced by 6.1±0.7 in B group,and in A group 3.3±0.9（P0.05）.The total times of exercises was increased by（63.6±2.3）s in B group,and in A group（31.6±2.2）s.Conclusion In the base of traditional medical therapy,patients with unstable angina pectoris will benefit from clopidogrel therapy,and clopidogrel has good security and tolerance,also.