摘要
目的研究桑枝提取物对糖尿病大鼠血糖及氧化应激的影响。方法采用四氧嘧啶复制糖尿病大鼠模型,灌胃给药4周后测定空腹血糖(FPG)、血清超氧化物歧化酶(SOD)活性、血清及肝脏中丙二醛(MDA)水平。结果桑枝提取物能够明显降低糖尿病大鼠血糖、提高血清SOD活性、降低MDA的含量,与对照组相比,差异有统计学意义(P<0.05)。结论桑枝提取物可降低糖尿病大鼠血糖并能够提高其抗氧化能力。
Objective To study the effects of Ramulus mori extracts on blood glucose and peroxidation in diabetic rats.Methods Copy diabetic rat model using alloxan,were given medicine for 4 weeks and the levels of blood glucose,serum superoxide dismutase（SOD）activity,malondialdehyde（MDA）were measured.Results Serum SOD of rats in DM group significantly decreased than that of normal control group;serum and MDA in liver and pancreas significantly increased than that of normal control group（P0.01）.After treatment by Ramulus mori extracts,blood glucose levels in diabetic rats decreased,serum SOD levels had a greater increase,the content of serum and MDA in liver and pancreas significantly decreased.Compared with the control group,there was a significant difference（P0.05）.Conclusion Ramulus mori extracts can reduce blood glucose in diabetic rats and improve their oxidation resistance.This may have positive significance for preventing the occurrence of diabetes and its complications.
出处
《中国实用医药》
2010年第9期29-30,共2页
China Practical Medicine
基金
山东省中医管理局中医药科技发展计划项目(项目编号:2007-204)
关键词
桑枝提取物
糖尿病模型
氧化应激
Ramulus mori extracts
Diabetes model
Oxidative stress
