辛伐他汀对老年高血压患者血管内皮功能的影响

Effect of Simvastatin to vascular epithelial function of elder patient with hypertension

目的探讨辛伐他汀对高血压患者血管内皮功能的影响。方法120例老年高血压患者随机分为治疗组及对照组，治疗组在常规治疗基础上，给予辛伐他汀治疗4周，剂量20mg／d，对照组常规治疗，测量2组治疗前后血压及血浆一氧化氮（NO）和内皮素（ET-1）水平。结果经辛伐他汀治疗4周后，收缩压及舒张压较治疗组均明显下降（P〈0．01），但心率变化不显著（P〉0．05）。治疗4周后血浆NO水平较治疗组显著升高（P〈0．05），且分期越高，血浆NO及ET-1浓度变化越显著。结论辛伐他汀可以显著地修复和改善EH不良的血管内皮结构及功能，有效增加降压药的疗效。

Objective Study the influence of Simvastatin on vascular epithelial function in hypertension patients. Methods Randomly divide 120 elder hypertension patients into two groups-the control group provided routine treatment and the treatment group given 20mg per day for a period of four weeks on top of the routine treatment; measure the change of their blood pressure, serum levels of nitric oxide and enodthelin-1 after the four weeks. Results In the treatment group, the patients＇ both of systolic and dialatic pressures decrease significantly as compared with the control group, yet their rhythm of heartbeat seems to have changed unnoticeable; their serum level of nitric oxide increases and enodthelin-1 level decreases significantly; additionally, the higher grade of hypertension, the more obvious change of serum levels of nitric oxide and enodthelin-1. Conclusion Simvastatin could promote the function of vascular epithelial function, and is helpful in treatment of hypertension.