我院门诊抗菌药物临床应用调查分析

Review of Outpatient Utilization of Antibiotics in Our Hospital

目的:了解我院门诊抗菌药物临床应用情况,结合抗菌药物的相关知识,进一步加强对抗菌药物临床应用原则的认识,从而做到合理用药。方法:随机抽取我院2008年6～12月门诊处方13162张,对其中抗菌药物的处方数、应用的抗菌药物的种类及数量、用药频度(DDDs)、相关药物的联用情况等进行归纳分析。结果:共统计处方13162张,其中抗菌药处方4939张,占总处方量的37.52%;单一使用抗菌药物的处方4093张,占抗菌药物处方总量的82.87%;二联用抗菌药物的处方为812张,占抗菌药物处方总量的16.44%;三联用抗菌药物的处方为34张,占抗菌药物处方总量的0.60%。结论:我院门诊抗菌药物的使用基本合理,但仍然存在问题,需进一步改善。头孢菌素类的使用量占医院抗菌药物的首位,大环内酯类(克拉霉素)、青霉素类和氟喹诺酮类的使用量较大。为延缓细菌耐药性的产生,建议进一步规范化管理抗菌药物的临床应用。掌握医院抗菌药物的应用情况,对于促进合理用药具有重要意义。

OBJECTIVE： To investigate the status quo of the outpatient use of antibiotics in our hospital,and to get a better understanding of the principle of utilization of antibacterial drugs based on our knowledge on antibacterials so as to achieve rational drug use. METHODS： A total of 13 162 outpatient prescriptions from June 2008 to December 2008 in our hospital were randomly collected for a statistical analysis in respect of the number of prescriptions of antibacterial drugs,number of varieties and consumption quantity of antibacterial drugs,DDDs and combined used of related drugs etc. RESULTS： Of the total 13 162 prescriptions examined,4 939 （37. 52% ） were prescriptions of antibacterial drugs; 4 093 （82. 87% ） prescribed 1 kind of antibiotics and 812 （16. 44% ） prescribed 2 kinds of antibiotics and 34 （0. 60% ） prescribed 3 kinds of antibacterial drugs. CONCLUSION： The outpatient use of antibacterials in our hospital is basically reasonable yet there some problems remain to be tackled. Cephalosporin dominated the first place among all the antibacterial drugs used in our hospital; and the consumption amount of Macrolides including Clarithromycin,Penicillins and Quinolones are on the high side. To delay bacterial drug resistance,it is suggested that the utilization of cephalosporin antibiotics be further standardized. Information of utilization of antibacterial drugs is of great significance for hospital rational drug use.