摘要
目的:了解药品不良反应(ADR)发生的特点、规律及影响因素,为临床合理用药提供参考。方法:对2008年我院已上报国家食品药品监督管理局ADR监察中心的267例报告,按患者的年龄和性别、怀疑药品的种类、给药途径、ADR所累及的系统、器官及主要临床表现、处置及转归等信息进行回顾性统计分析。结果:引起ADR的怀疑药品以抗感染药高居首位,共195例,占70.03%;给药途径以静脉输注为主,共241例,占90.26%;ADR所累及的系统、器官以皮肤及其附件损害最为普遍,共162例,占60.62%。结论:ADR的发生与药物理化性质、用法用量及药物间的相互作用等多种因素有关,加强ADR监测工作应注意ADR高发药物的使用。
OBJECTIVE： To probe into the characteristics,regularity and influencing factors of the adverse drug reactions （ADR） in 2008 in Changshu No. 1 People’s Hospital so as to provide references of clinical rational drug use. METHODS： A total of 267 ADR cases submitted to State Food and Drug Administration by our hospital in 2008 were subjected to statistical analysis in respect of patients’age and sex,categories of suspicious drugs,route of administration, system and organs involved,major clinical manifestations,management of ADRs and outcomes etc. RESULTS： The ADR was mainly caused by anti - infectives （195 cases,accounting for 70. 03%）. The leading route of administration which caused ADR was intravenous drip infusion （241 cases,accounting for 90. 26%）. Lesions of skin and its annex were the most common clinical manifestations of ADR （accounting for 60. 62%）. CONCLUSION： The occurrence of ADR is related to physical and chemical properties of drugs,usage and dosage,drug interactions and other factors. ADR monitoring should be intensified and great importance should be attached to the drugs with high ADR incidences.
出处
《中国医院用药评价与分析》
2010年第3期266-269,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
键词药品不良反应
用药分析
用药监测
Adverse drug Reaction （ADR）
Analysis of drug use
Monitoring on drug use
