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自然杀伤细胞抗肿瘤治疗研究进展 被引量：1

A dvances in research of anti-tumor treatment with natural killer cells
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摘要 自然杀伤(NK)细胞是最重要的抗肿瘤免疫细胞。提高NK细胞抗瘤活性的最新研究包括:同种异体NK细胞过继性免疫治疗;通过基因工程的方法使肿瘤细胞表达肿瘤抗原特异性嵌合受体;选择具有高亲和力Fc受体NK细胞,联合单克隆抗体通过ADCC效应杀伤肿瘤细胞;提高靶细胞对NK细胞介导的凋亡的敏感性;解除抑制因素对NK细胞的影响;促进NK细胞浸润肿瘤组织及淋巴结;NK细胞不同亚群间的功能差异研究。
作者 刘辉 杨波 焦顺昌
机构地区 解放军总医院肿瘤科
出处 《军医进修学院学报》 CAS 2010年第4期398-400,共3页 Academic Journal of Pla Postgraduate Medical School
基金 军队"十一.五"攻关课题(06G106)~~
关键词 杀伤细胞 天然 肿瘤 免疫疗法
分类号 R73 [医药卫生—肿瘤]
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参考文献24

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同被引文献11

  • 1徐宝连,魏克民.白血病的免疫治疗进展[J].医学综述,2007,13(6):413-415. 被引量：2
  • 2Sanchez-Correa B,Morgado S. Human NK cells in acute myeloid leukaemia patients:analysis of NK cell-activating receptors and their ligands[J].Cancer Immunology Immunotherapy,2011,(08):1195-1205.
  • 3Verheyden S,Demanet C. NK cell receptors and their ligands in leukemia[J].Leukemia:Official Journal of the Leukemia Society of America,Leukemia Research Fund,U.K,2008,(02):249-257.
  • 4Brusilovsky M,Rosental B,Shemesh A. Human NK cell recognition of target cells in the prism of natural cytotoxicity receptors and their ligands[J].J Immunotoxicol,2012,(03):267-274.
  • 5Ramachandran C,Wilk B J,Hotchkiss A. Activation of human T-helper/inducer cell,T-cytotoxic cell,B-cell,and natural killer (NK)-cells and induction ofnatural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin[J].BMC Complementary and Alternative Medicine,2011,(11):59-67.
  • 6Cheuk AT,Wells JW,Chan L. Anti-tumor immunity in a model of acute myeloid leukemia[J].Leukemia and Lymphoma,2009,(03):447-454.
  • 7于建渤,刘卫平.人类自然杀伤细胞发育研究进展[J].细胞与分子免疫学杂志,2009,25(1):87-88. 被引量：1
  • 8田志刚.基于NK细胞的肿瘤免疫治疗研究进展[J].中国肿瘤生物治疗杂志,2009,16(1):2-5. 被引量：24
  • 9苏龙,郭丽新,刘力华.Unlicensed NK细胞的免疫效应[J].中国免疫学杂志,2010,26(9):855-858. 被引量：1
  • 10付笑迎,吴长有.记忆性NK细胞的研究进展[J].中国免疫学杂志,2010,26(12):1141-1142. 被引量：1

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军医进修学院学报
2010年 第4期

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