不同应力水平的持续运动对生长期大鼠骨形态计量学参数的影响

Different Impact training on Histomorphometric Properties of Growing Rats' Bone

为了探讨不同应力水平的运动对生长期大鼠的长骨生长发育的影响,将24只4周龄雌性SD大鼠随机分为对照组,游泳运动组和跑台运动组,每组8只,游泳运动组和跑台运动组分别进行为期9周,每周5次,每次60分钟的游泳运动和跑台运动。取后肢胫骨进行骨组织形态计量学指标的测定。结果显示:运动组的骨小梁体积、骨小梁平均宽度、皮质骨宽度、类骨质表面积和类骨质厚度均极显著地高于对照组,而骨小梁分离度、侵蚀表面积则极显著地低于对照组。跑台运动组的骨小梁体积、骨小梁平均宽度和类骨质厚度非常显著地高于游泳组,骨小梁的分离度、侵蚀表面积非常显著地低于游泳组,这些实验结果提示:两种方式的运动均能够通过促进骨形成、抑制骨吸收促进生长期大鼠胫骨骨量的积累,而且持续跑台运动的成骨作用大于持续游泳运动。

To investigate the effect of different impact exercise on growing bone,24 female SD rats（5 weeks old） were randomly assigned to a running group（Run n=8）,a swimming group（Swim,n=8） and a control group（con,n=8）.During a 9 weeks training session（20～60 min/day,5 days/week）,the Run rats were trained at progressively increasing running speeds（10～20 m/min）,and weights attached to the tail of the Swim rats from the 4th week and then on.BV/TV%,Tb.Th,Tb.N,Os/Bs,O.Th of Run and Swim are all significantly higher than in the Con group,and these parameters of Run are all significantly higher than that of Swim.Tb.Sp and Es/Bs of this two exercise groups are all significantly lower than that of the Con group,and the parameters of Run are also significantly lower than that of the Swim.The data suggest that all exercise modes can simulate bone formation and suppress bone resorption,the effect of prolonged swimming on bone growth is less obvious than that of prolonged running.