长寿老年人血脂代谢特点及其临床意义

Characteristics and clinical significance of serum lipids metabolism in longevity patients

目的探讨长寿老年人血脂代谢的特点及其临床意义。方法 145例90岁以上长寿老年人为长寿组,151例75岁以下一般老年人为对照组,分别测定其血脂各项指标,同时对其临床情况进行对比分析。结果与对照组比较,长寿组血清TC、TG、LDL-C、载脂蛋白A-Ⅰ(apoA-Ⅰ)、载脂蛋白B(apoB)明显降低,2组HDL-C差异无统计学意义;长寿组HDL-C/TC、HDL-C/LDL-C和apoA-Ⅰ/apoB较对照组明显升高,差异有统计学意义(P<0.05,P<0.01)。2组高血压、糖尿病、冠心病的发病率差异无统计学意义,但长寿组心肌梗死发病率及服用调脂药物的比例明显低于对照组。结论长寿老年人血脂代谢的特点可能是寿命延长的原因之一。

Objective To investigate the characteristics of serum lipid levels and its clinical significance in longevity patients. Methods The levels of fast serum lipids of 145 persons over 90 years old（longevity group） and 151 patients aged from 50 to 75 years old（control group） were measured, and their underlying diseases were compared. Results Compared with the control group, the values of TC,TG,LDL-C,apolipoprotein A- Ⅰ（apoA- Ⅰ ） and apolipoprotein B（apoB） were significantly lower,however, HDL-C/TC, HDL-C/LDL-C and apo A- Ⅰ/apoB were higher in the longevity group. There was no significant difference in HDL-C level between the two groups. There was also no difference in the morbidity of hypertension,diabetes mellitus and coronary artery disease between the two groups, but the morbidity of myocardial infarction was lower in longevity group. The proportion of using lipid-lowering medicines was lower in longevity group, but no dose difference between the two groups （P 〈0. 05,P 〈 0. 01）. Conclusions The characteristics of lipid levels in longevity persons may be one of the factors causing long life.