胃食管反流性咳嗽的发病机制及诊疗

Pathogenesis, diagnosis and treatment of gastroesophageal reflux-related chronic cough

胃食管反流性咳嗽为胃食管反流病的一种特殊类型，是慢性咳嗽常见病因之一。与典型胃食管反流病相比，胃食管反流性咳嗽在发病机制、诊疗方面有其特点。胃食管反流性咳嗽的发病机制可能是高位反流、低位反流和气道高敏感性等多因素共同作用的结果，诊断需结合临床表现和辅助检查建立，多通道食管腔内阻抗联合pH监测可以区分酸与非酸性反流，是有前景的诊断技术，抗反流药物治疗是目前胃食管反流性咳嗽的主要治疗方法。

Gastroesophageal reflux cough, a special type of gastroesophageal reflux disease, is considered as one of the most common causes of chronic cough. However, gastroesophageal reflux cough has its own characteristics in pathogenesis, diagnosis and treatment. It has associated with distal or proximal reflux and airway hypersensitivity. The diagnosis of gastroesophageal reflux cough is dependent upon the combination of clinical presentation and laboratory investigations. Muhichannel intraluminal esophageal impedance and pH monitoring is a promising technique developed recently which is able to detect both acid and non-acid reflux. Currently, anti-reflux therapy with drugs is still the main approach for gastroesophageal reflux cough.