摘要
胰高血糖素样肽-1(GLP-1)具备多重抗高血糖作用。近年来基于其治疗2型糖尿病的方案已成为新的研究热点并引起广泛关注。它的几种类似物作为新的降糖药物相继完成Ⅲ期临床研究并在一些国家上市。现就GLP-1的结构、功能,以及几种相关降糖药物的临床研究做一概述。
GLP-1 has muhiple effect on anti-hyperglycemia,thus the therapy based on GLP-1 in type 2 diabetes mellitus has been extensive reported. Accompanied with the completion of phase m study, GLP-Ⅰ analogues were lunched in some countries. This review focuses on the structure and functions of GLP-1, and the updated clinical development on the agents based on it.
出处
《国际内分泌代谢杂志》
2010年第2期94-96,共3页
International Journal of Endocrinology and Metabolism