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Kisspeptin／GPR54系统与能量代谢的关系 被引量：3

Relationship between kisspeptin/GPR54 system and energy metabolism
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摘要 营养状态和有效的能量储存可影响生育能力，但是连接能量代谢和生殖的细胞和分子机制还不十分清楚。研究表明，kisspeptin／G蛋白耦联受体（GPR）54系统是生殖系统的主要调控者，但近年的研究发现，能量平衡状态以及一些代谢因子能影响下丘脑KISS-1或GPR54的表达，从而影响下丘脑-垂体-性腺轴的功能。因此，下丘脑kisspeptin／GPR54系统可能在将机体能量代谢信息传递给调控生殖轴的中枢过程中有重要作用。 Fertility is gated by nutrition and the availability of stored energy reserves, but the cellular and molecular mechanisms link energy stores and reproduction are not well understood. Several lines of evidence have substantiated the pivotal function of the kisspeptin/GPR54 system as a major gatekeeper of the reproductive axis. In addition, nutritional status and peripheral signal （ s ） can modulate the hypothalamic KISS-1/GPR54 system. Accordingly, the hypothalamic kisspeptin/GPR54 system might play a physiological role in relaying the state of body energy stores and metabolic fuels to the centers governing the reproductive axis.
作者 胡雅婷 温俊平 陈刚
机构地区 福建医科大学省立临床医院内分泌科
出处 《国际内分泌代谢杂志》 2010年第2期110-112,共3页 International Journal of Endocrinology and Metabolism
基金 基金项目：国家自然科学基金资助项目（30900510） 福建省科技厅青年人才项目基金资助项目（2008F3032）
关键词 能量代谢 KISS-1基因 GPR54 生殖 Energy metabolism KISS-1 gene GPR54 Reproduction
分类号 R341 [医药卫生—基础医学]
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参考文献17

  • 1Kauffman AS,Clifton DK,Steinsr RA.Emerging ideas ahont kiaspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction.Trends Neurosci,2007,30:504-511.
  • 2de Roux N,Genin E,Carol JC,et al.Hypagonadotropic hypogonadism due to loss of function of the KISS1-derived peptide receptor GPR54.Proc Natl Acad Sci U S A,2003,100:10972-10976.
  • 3Harms JF,Weleh DR,Miele ME.KISS-1 metastasis suppression and emergent pathway.Clin Exp Metastasis,2003,20:11-18.
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同被引文献32

  • 1甘晓红,洪华珠,肖君华.GPR54及其配体与青春期发育[J].国际内分泌代谢杂志,2006,26(6):424-426. 被引量：7
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  • 3Lee DK, Nguyen T, O'Neill GP, et al.Discovery of a receptor related to the galanin receptors[J]. FEBS Lett, 1999, 446:103- 107.
  • 4Muir AI, Chamberlain L, Elshourbagy NA, et al. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-I[J]. J Biol Chem, 2001,276:28969-28975.
  • 5Harms JF, Welch DR, Miele ME. KISS1 metastasis suppression and emergent pathways[J]. Clin Exp Metastasis, 2003,20:11-18.
  • 6Adachi S, Yamada S, Takatsu Y, et al. Involvement of anteroventral periventrieular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats[J]. J Reprod Dev, 2007,53:367-378.
  • 7S6bert ME, Lomet D, Said SB, et al. Insights into the mechanism by which kisspeptin stimulates a preovulatory LH surge and ovulation in seasonally acyclic ewes: potential role of estradiol[J]. Domest Anita Endocrinol, 2010,38:289-298.
  • 8Steiner RA. Kisspeptin: past, present, and prologue[J]. Adv Exp Med Biol. 2013.784:3-7.
  • 9Smith JT, Dungan HM, Stoll EA, et al. Differential regulation of KISS- 1 mRNA expression by sex steroids in the brain of the male mouse[J]. Endocrinology, 2005,146:2976-2984.
  • 10Pineda R, Gareia-Galiano D, Roseweir A, et al. Critical roles of kisspeptins in female puberty and preovnlatory gonadotropin surges as revealed by a novel antagonist[J]. Endocrinology, 2010,151:722-730.

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国际内分泌代谢杂志
2010年 第2期

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