坦索罗辛治疗根治性子宫切除术后尿潴留的临床研究

Clinical study of tamsulosin in prevention of urinary retention after radical hysterectomy

目的研究坦索罗辛对根治性子宫切除术后尿潴留的治疗和预防效果。方法将66例行根治性子宫切除术患者按随机数字表法分为两组：试验组和对照组，每组各33例。试验组术后第10天开始睡前口服坦索罗辛0．2mg，1次，d，共3d；对照组口服淀粉制成的安慰剂。比较两组留置导尿管时间、第一次拔导尿管后残余尿量、尿潴留和尿路感染发生情况、术后住院时间以及药物不良反应等。结果试验组留置导尿管时间、术后住院时间均短于对照组（P〈0．05）。试验组第一次拔导尿管后残余尿量（38．2±5．6）ml，对照组为（168．5±11．8）ml，两组比较差异有统计学意义（P〈0．05）。试验组尿潴留发生率为18．2％（6／33），对照组为36．4％（12／33），两组比较差异有统计学意义（P〈0．05）。试验组未发现因为应用坦索罗辛而发生明显不良反应。结论坦索罗辛是预防和治疗根治性子宫切除术后尿潴留安全有效的药物。

Objective To study the clinical value of tamsulosin in prevention of urinary retention after radical hysterectomy. Methods Sixty-six patients after radical hysterectomy were enrolled in this study, and divided into two groups in random. Thirty-three cases in the treatment group were treated with tamsulosin 0.2 mg once every night, 3 days before the catheter was drawn. While 33 cases in the control group only with placebo. Catheter keeping days, residual urine volume at first extraction,the rate of urinary retention and urinary tract infection, hospitalization time and drug adverse reaction were compared in two groups. Results Catheter keeping days and hospitalization time were shorter in the treatment group than those in the control group（P 〈 0.05 ）. The residual urine volume at first extraction was （38.2 ± 5.6） ml in the treatment group and （168.5 ± 11.8） ml in the control group,there was significant difference between two groups （P 〈 0.05 ）. The rate of urinary retention was 18.2% （6/33） in the treatment group and 36.4% （ 12/33 ） in the control group,there was significant difference between two groups （P 〈 0.05 ）. There was no adverse reaction resulted from tamsulosin in the treatment group. Conclusion Tamsulosin is an effective drug which could prevent and treat the urinary retention after radical hysterectomy.