甲基泼尼松龙脉冲治疗Graves’眼病

Pulse treatment with methylprednisolone on Graves' ophthalmopathy

目的评价大剂量甲基泼尼松龙脉冲治疗Graves’眼病的疗效。方法采用大剂量甲基泼尼松龙脉冲治疗Graves’眼病12例。予甲基泼尼松龙10～15mg／（kg·d）静脉滴注，隔日重复1次；2周后重复以上治疗方法；然后甲基泼尼松龙剂量减半后同上述方法再治疗4次，整个疗程2个月。结果12例患者经治疗后眼部症状均得到一定改善，显效率达58％。结论大剂量甲基泼尼松龙脉冲治疗Graves’眼病有效且安全，尤其对病程短、病变活动程度较高的患者疗效好。

Objective It is to investigate the clinical effect of pulse treatment with high-dose methylprednisolone on Graves＇ ophthalmopathy. Methods Twelve patients with Graves＇ ophthalmopathy were taken high-dose methylprednisolone pulse therapy by intravenous infusing at the dose of 10 - 15 mg/（kg·d） and then repeated every two day. This treatment mentioned above was taken again after two weeks. In the second months, the above method was used four times at the halved dose of methylprednisolone. The treatment course was 2 months. Results Eye symptoms of twelve patients were im- proved at a certain degree after treatment with a significant effective rate of 58%. Conclusion The pulse treatment of Graves＇ ophthalmopathy by high-dose methylprednisolone is effective and safe, and it especially has good curative effect for patients who have short disease course and have higher levels of disease activity.