摘要
采用微波辅助、HCl做催化剂,合成2-氨甲基苯并咪唑。探讨了物料比、微波输出功率和微波辐射时间对反应产率的影响。结果表明:较佳反应条件为邻苯二胺∶甘氨酸=1∶2,微波输出功率259 W,间歇辐射50 min。该方法具有原料消耗少、操作简单、反应条件温和、易纯化、对环境无污染、产率高的优点。
The synthesis of 2-aminomethylbenzimidazole using hydrochloric acid as catalyst was reported under microwave irradiation.The influence of the mole ratio of materials,output power,reaction time on yield were investigated.Optimal reaction condition were obtained： the ratio of o-phenylendiamine to glycine： 1∶2（mole）,output power： 259 W,intermit radiate time： 50 minutes,total yield： 77%.Compared to the previous methods,this new method has the advantages of simple procedure,mild conditions,easy purification,and good yield.
出处
《西北林学院学报》
CSCD
北大核心
2010年第3期167-169,共3页
Journal of Northwest Forestry University
基金
陕西省科技攻关(中药现代化)项目[2007K11-G7(13)]
关键词
2-氨甲基苯并咪唑
微波
合成
2-aminomethylbenzimidazole
microwave
synthesis
