3-苯基异香豆冉酮衍生物的不对称Mannich反应研究

Study on the Mannich Reaction of 3-Phenyl Isocoumaranone Derivatives

研究了双功能手性硫脲-叔胺催化剂催化的3-苯基异香豆冉酮衍生物与Ⅳ．保护亚胺的不对称Mannich反应，高收率、高对映选择性（88％-98％）地合成了一系列具有连续季碳叔碳手性中心的新化合物，其结构经1^H NMR和13^C NMR表征。

The asymmetric Mannich reaction of 3-phenyl i ne derivatives and N-protected imines were investigated using bifunctional thiourea-tertiary amine as the catalyst. A series of novel transformation afforded Mannich adducts bearing adjacent quaternary carbon and tertiary carbon chiral centers with high yield and excellent enantioselectivities （88% ee - 98% ee）. The structures were characterized by 1^H NMR and 13^C NMR.